Gene

tubb5

ID
ZDB-GENE-031110-4
Name
tubulin, beta 5
Symbol
tubb5 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have GTP binding activity. Involved in fin regeneration. Predicted to localize to cytoplasm and microtubule. Is expressed in midbrain hindbrain boundary neural keel; nervous system; optic vesicle; and spinal cord neural tube. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 6. Orthologous to human TUBB (tubulin beta class I).
Genome Resources
Note
None
Expression
All Expression Data
13 figures from 7 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tubb5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
complex cortical dysplasia with other brain malformations 6 Alliance Cortical dysplasia, complex, with other brain malformations 6 615771
Symmetric circumferential skin creases, congenital, 1 156610
Associated With tubb5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR013838 Beta tubulin, autoregulation binding site
Conserved_site IPR017975 Tubulin, conserved site
Domain IPR003008 Tubulin/FtsZ, GTPase domain
Domain IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
Family IPR000217 Tubulin
Family IPR002453 Beta tubulin
Homologous_superfamily IPR008280 Tubulin/FtsZ, C-terminal
Homologous_superfamily IPR023123 Tubulin, C-terminal
Homologous_superfamily IPR036525 Tubulin/FtsZ, GTPase domain superfamily
Homologous_superfamily IPR037103 Tubulin/FtsZ, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Beta tubulin Beta tubulin, autoregulation binding site Tubulin Tubulin, conserved site Tubulin, C-terminal Tubulin/FtsZ, 2-layer sandwich domain Tubulin/FtsZ, C-terminal Tubulin/FtsZ, C-terminal domain superfamily Tubulin/FtsZ, GTPase domain Tubulin/FtsZ, GTPase domain superfamily
UniProtKB:Q6NW90 444
UniProtKB:Q8AYC4 444
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations