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ZIRC
ZFIN ID: ZDB-GENE-031110-4
Gene Name: tubulin, beta 5
Gene Symbol: tubb5    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have GTP binding activity. Involved in fin regeneration. Predicted to localize to the cytoplasm and microtubule. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 6. Is expressed in midbrain hindbrain boundary neural keel; nervous system; optic vesicle; and spinal cord neural tube. Orthologous to human TUBB (tubulin beta class I).
Genome Resources: Alliance (1),  Gene:386701 (1),  Ensembl(GRCz11):ENSDARG00000037997 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa42668 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tubb5 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tubb5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    complex cortical dysplasia with other brain malformations 6 Alliance Cortical dysplasia, complex, with other brain malformations 6 615771
    Symmetric circumferential skin creases, congenital, 1 156610
    DISEASE ASSOCIATED WITH tubb5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fin regeneration (more)
    Cellular Component cytoskeleton (more)
    Molecular Function structural molecule activity (more)
    GO Terms (all 12)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tubb5-201 (1)    Ensembl 2319
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tubb5 No data available
    MARKER RELATIONSHIPS
    tubb5 Contained in: [BAC] CH73-309N4 (1) (order this), DKEYP-77H1 (1)
    tubb5 Encodes: [cDNA] MGC:85895 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_198818 (1) 2292 bp
    Genomic GenBank:CR848747 182850 bp
    Select Tool
    Polypeptide UniProtKB:Q6NW90 (1) 444 aa
    Sequence Clusters UniGene:35891 (1)
    Sequence Information (all 18)
    ORTHOLOGY for tubb5 ( Chr: 16 )
    CITATIONS (40)