Gene
cyp2aa3
- ID
- ZDB-GENE-031030-8
- Name
- cytochrome P450, family 2, subfamily AA, polypeptide 3
- Symbol
- cyp2aa3 Nomenclature History
- Previous Names
-
- zgc:63546
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 family 2 | Cytochrome P450 superfamily |
---|---|---|---|---|---|---|
UniProtKB:B3DJ50
|
496 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
cyp2aa3-201
(1)
|
Ensembl | 1,704 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_198369 (1) | 1704 nt | ||
Genomic | GenBank:CT997819 (2) | 189527 nt | ||
Polypeptide | UniProtKB:B3DJ50 (1) | 496 aa |
No data available
- Shi, X.C., Sun, J., Jin, A., Ji, H., Yu, H.B., Li, Y., Li, X.X., Liu, P., Li, C., Huang, J.Q. (2018) Cytochrome P450 2AA molecular clone, expression pattern, and different regulation by fish oil and lard oil in diets of grass carp (Ctenopharyngodon idella). Fish physiology and biochemistry. 44(4):1019-1026
- Chatzopoulou, A., Schoonheim, P.J., Torraca, V., Meijer, A.H., Spaink, H.P., Schaaf, M.J. (2017) Functional analysis reveals no transcriptional role for the glucocorticoid receptor β-isoform in zebrafish. Molecular and Cellular Endocrinology. 447:61-70
- Puthumana, J., Kim, B.M., Jeong, C.B., Kim, D.H., Kang, H.M., Jung, J.H., Kim, I.C., Hwang, U.K., Lee, J.S. (2017) Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P gene families in the mangrove killifish Kryptolebias marmoratus genome: Identification and expression in response to B[α]P, BPA, OP, and NP. Aquatic toxicology (Amsterdam, Netherlands). 187:132-140
- Chen, J., He, J., Li, L., Yang, D., Luo, L. (2016) Cyp2aa9 regulates haematopoietic stem cell development in zebrafish. Scientific Reports. 6:26608
- Driessen, M., Kienhuis, A.S., Vitins, A.P., Pennings, J.L., Pronk, T.E., Brandhof, E.J., Roodbergen, M., Water, B.V., Ven, L.T. (2014) Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans. Toxicology letters. 230(1):48-56
- Kubota, A., Bainy, A.C., Woodin, B.R., Goldstone, J.V., and Stegeman, J.J. (2013) The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): Expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicology and applied pharmacology. 272(1):172-9
- Yuan, L., Lv, B., Zha, J., Wang, Z., Wang, W., Li, W., and Zhu, L. (2013) New cytochrome P450 1B1, 1C1, 2Aa, 2Y3, and 2K genes from Chinese rare minnow (Gobiocypris rarus): Molecular characterization, basal expression and response of rare minnow CYP1s and CYP2s mRNA exposed to the AHR agonist benzo[a]pyrene. Chemosphere. 93(2):209-16
- Goldstone, J.V., McArthur, A.G., Kubota, A., Zanette, J., Parente, T., Jonsson, M.E., Nelson, D.R., and Stegeman, J.J. (2010) Identification and developmental expression of the full complement of cytochrome P450 genes in zebrafish. BMC Genomics. 11:643
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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