Gene
akt2
- ID
- ZDB-GENE-031007-5
- Name
- v-akt murine thymoma viral oncogene homolog 2
- Symbol
- akt2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Involved in several processes, including bone development; glucose homeostasis; and positive regulation of glucose import. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); malignant glioma; and reproductive organ cancer (multiple). Is expressed in several structures, including brain; gill; heart; muscle; and pleuroperitoneal region. Orthologous to human AKT2 (AKT serine/threonine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypoinsulinemic hypoglycemia with hemihypertrophy | Alliance | Hypoinsulinemic hypoglycemia with hemihypertrophy | 240900 |
| type 2 diabetes mellitus | Alliance | Diabetes mellitus, type II | 125853 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR034677 | Protein Kinase B beta, catalytic domain |
| Domain | IPR039026 | Protein Kinase B, pleckstrin homology domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein Kinase B beta, catalytic domain | Protein Kinase B, pleckstrin homology domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8UUX0
|
479 |
Interactions and Pathways
No data available
Plasmids
No data available