Gene
akt2
- ID
- ZDB-GENE-031007-5
- Name
- v-akt murine thymoma viral oncogene homolog 2
- Symbol
- akt2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including bone development; glucose homeostasis; and positive regulation of D-glucose import. Is expressed in several structures, including brain; gill; heart; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb504 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb505 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| la020441Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7448 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa23364 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ya349 | Allele with one insertion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-akt2 | (2) | |
| CRISPR2-akt2 | Zhou et al., 2024 | |
| MO1-akt2 | N/A | Jensen et al., 2010 |
| MO2-akt2 | N/A | Jensen et al., 2010 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypoinsulinemic hypoglycemia with hemihypertrophy | Alliance | Hypoinsulinemic hypoglycemia with hemihypertrophy | 240900 |
| type 2 diabetes mellitus | Alliance | Diabetes mellitus, type II | 125853 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein Kinase B beta, catalytic domain | Protein Kinase B, pleckstrin homology domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8UUX0 | InterPro | 479 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(lyz:akt2-EGFP) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-76G6 | ZFIN Curated Data | |
| Contained in | BAC | CH211-132B12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153876 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192688 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198146 (1) | 3364 nt | ||
| Genomic | GenBank:BX664607 (1) | 179328 nt | ||
| Polypeptide | UniProtKB:Q8UUX0 (1) | 479 aa |
- Benchoula, K., Serpell, C.J., Mediani, A., Albogami, A., Misnan, N.M., Ismail, N.H., Parhar, I.S., Ogawa, S., Hwa, W.E. (2024) 1H NMR metabolomics insights into comparative diabesity in male and female zebrafish and the antidiabetic activity of DL-limonene. Scientific Reports. 14:38233823
- Gao, Y., Wu, Y., Tie, F., Wang, H. (2024) Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model. Heliyon. 10:e32007e32007
- Ulhaq, Z.S., Tse, W.K.F. (2024) PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease. Genes. 15(1):
- Zhang, H., Sun, C., Xia, Q., Li, P., Liu, K., Zhang, Y. (2024) Brevianamide F Exerts Antithrombotic Effects by Modulating the MAPK Signaling Pathway and Coagulation Cascade. Marine drugs. 22(10):
- Zhang, L., Liu, H., Zhang, H., Yuan, H., Ren, D. (2024) Lemairamin (Wgx-50) Attenuates DSS-Induced Intestinal Inflammation in Zebrafish. International Journal of Molecular Sciences. 25(17):
- Zhou, W., Ghersi, J.J., Ristori, E., Semanchik, N., Prendergast, A., Zhang, R., Carneiro, P., Baldissera, G., Sessa, W.C., Nicoli, S. (2024) Akt is a mediator of artery specification during zebrafish development. Development (Cambridge, England). 151(17):
- Kang, Q., Zheng, J., Jia, J., Xu, Y., Bai, X., Chen, X., Zhang, X.K., Wong, F.S., Zhang, C., Li, M. (2022) Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish. The Journal of biological chemistry. 298(12):102665
- Lu, Y., Tang, D., Zheng, Z., Wang, X., Zuo, N., Yan, R., Wu, C., Ma, J., Wang, C., Xu, H., He, Y., Liu, D., Liu, S. (2022) Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Frontiers in molecular neuroscience. 15:844668
- Sun, C.C., Yang, D., Chen, Z.L., Xiao, J.L., Xiao, Q., Li, C.L., Zhou, Z.Q., Peng, X.Y., Tang, C.F. (2022) Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction. The FEBS journal. 290(6):1519-1530
- Jia, S., Wu, X., Wu, Y., Cui, X., Tao, B., Zhu, Z., Hu, W. (2020) Multiple Developmental Defects in sox11a Mutant Zebrafish with Features of Coffin-Siris Syndrome. International journal of biological sciences. 16:3039-3049
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