Gene
rpl13
- ID
- ZDB-GENE-031007-1
- Name
- ribosomal protein L13
- Symbol
- rpl13 Nomenclature History
- Previous Names
-
- zgc:92272 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within embryonic cranial skeleton morphogenesis and regulation of cell cycle. Predicted to be located in cytoplasm and ribosome. Predicted to be part of cytosolic large ribosomal subunit. Used to study spondyloepimetaphyseal dysplasia. Orthologous to human RPL13 (ribosomal protein L13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6910738 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Spondyloepimetaphyseal dysplasia, Isidor-Toutain type | 618728 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| spondyloepimetaphyseal dysplasia | rpl13upv3/upv3 | standard conditions | Costantini et al., 2020 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Large ribosomal subunit protein eL13 | Large ribosomal subunit protein eL13, conserved site |
|---|---|---|---|---|
| UniProtKB:Q90Z10 | InterPro PDB | 211 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-352P16 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-68F2 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6910738 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92272 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198143 (1) | 663 nt | ||
| Genomic | GenBank:CU683900 (1) | 61935 nt | ||
| Polypeptide | UniProtKB:Q90Z10 (1) | 211 aa |
- Toh, P.J.Y., Lai, J.K.H., Hermann, A., Destaing, O., Sheetz, M.P., Sudol, M., Saunders, T.E. (2022) Optogenetic control of YAP cellular localisation and function. EMBO reports. 23(9):e54401
- Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Barthelson, K., Baer, L., Dong, Y., Hand, M., Pujic, Z., Newman, M., Goodhill, G.J., Richards, R.I., Pederson, S.M., Lardelli, M. (2021) Zebrafish Chromosome 14 Gene Differential Expression in the fmr1hu2787 Model of Fragile X Syndrome. Frontiers in genetics. 12:625466
- Bastos de Oliveira, M., Meier, K., Jung, S., Bartels-Klein, E., Coxam, B., Geudens, I., Szymborska, A., Skoczylas, R., Fechner, I., Koltowska, K., Gerhardt, H. (2021) Vasohibin-1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk. Development (Cambridge, England). 148(4):
- Okuda, K.S., Ng, M.F., Ruslan, N.F., Bower, N.I., Song, D.S.S., Chen, H., Baek, S., Crosier, P.S., Koltowska, K., Astin, J.W., Tan, P.J., Hogan, B.M., Patel, V. (2021) 3,4-Difluorobenzocurcumin Inhibits Vegfc-Vegfr3-Erk Signalling to Block Developmental Lymphangiogenesis in Zebrafish. Pharmaceuticals (Basel, Switzerland). 14(7):
- Steeman, T.J., Rubiolo, J.A., Sánchez, L.E., Calcaterra, N.B., Weiner, A.M.J. (2021) Conservation of Zebrafish MicroRNA-145 and Its Role during Neural Crest Cell Development. Genes. 12(7):
- Costantini, A., Alm, J.J., Tonelli, F., Valta, H., Huber, C., Tran, A.N., Daponte, V., Kirova, N., Kwon, Y.U., Bae, J.Y., Chung, W.Y., Tan, S., Sznajer, Y., Nishimura, G., Näreoja, T., Warren, A.J., Cormier-Daire, V., Kim, O.H., Forlino, A., Cho, T.J., Mäkitie, O. (2020) Novel RPL13 variants and variable clinical expressivity in a human ribosomopathy with spondyloepimetaphyseal dysplasia. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 36(2):283-297
- Cunha, V., Vogs, C., Le Bihanic, F., Dreij, K. (2020) Mixture effects of oxygenated PAHs and benzo[a]pyrene on cardiovascular development and function in zebrafish embryos. Environment International. 143:105913
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