Gene
mgll
- ID
- ZDB-GENE-031006-9
- Name
- monoglyceride lipase
- Symbol
- mgll Nomenclature History
- Previous Names
-
- cb909 (1)
- wu:fc66g01
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable monoacylglycerol lipase activity. Predicted to be involved in acylglycerol metabolic process. Predicted to be active in membrane. Is expressed in several structures, including EVL; basal plate midbrain region; brain; digestive system; and eye. Orthologous to human MGLL (monoglyceride lipase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb909 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029459Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mgll | N/A | Martella et al., 2016 |
| MO2-mgll | N/A | Martella et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | Alpha/beta hydrolase fold-1 | Monoacylglycerol and Diacylglycerol Lipase | Serine aminopeptidase, S33 |
|---|---|---|---|---|---|---|
| UniProtKB:Q7ZWC2 | InterPro | 300 | ||||
| UniProtKB:A0AB32TT74 | InterPro | 343 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-20D21 | ZFIN Curated Data | |
| Encodes | EST | cb909 | Thisse et al., 2001 | |
| Encodes | EST | fc66g01 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56561 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200297 (1) | 1638 nt | ||
| Genomic | GenBank:CR847503 (1) | 217514 nt | ||
| Polypeptide | UniProtKB:A0AB32TT74 (1) | 343 aa |
- Grepper, D., Tabasso, C., Aguettaz, A., Martinotti, A., Ebrahimi, A., Lagarrigue, S., Amati, F. (2023) Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids. Molecular metabolism. 68:101669
- Hu, R., Xu, Y., Han, B., Chen, Y., Li, W., Guan, G., Hu, P., Zhou, Y., Xu, Q., Chen, L. (2022) MiR-202-3p determines embryo viability during mid-blastula transition. Frontiers in cell and developmental biology. 10:897826
- Bian, W.P., Pu, S.Y., Xie, S.L., Wang, C., Deng, S., Strauss, P.R., Pei, D.S. (2021) Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish. Cell death discovery. 7:250
- Han, S.L., Qian, Y.C., Limbu, S.M., Wang, J., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2021) Lipolysis and lipophagy play individual and interactive roles in regulating triacylglycerol and cholesterol homeostasis and mitochondrial form in zebrafish. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(9):158988
- Knuth, M.M., Stutts, W.L., Ritter, M.M., Garrard, K.P., Kullman, S.W. (2021) Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish. Journal of Lipid Research. 62:100142
- Orr, S.A., Ahn, S., Park, C., Miller, T.H., Kassai, M., Issa, F.A. (2021) Social Experience Regulates Endocannabinoids Modulation of Zebrafish Motor Behaviors. Frontiers in behavioral neuroscience. 15:668589
- Zhang, W., Wu, C., Ni, R., Yang, Q., Luo, L., He, J. (2021) Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics. 17:e1009980
- Forner-Piquer, I., Beato, S., Piscitelli, F., Santangeli, S., Di Marzo, V., Habibi, H.R., Maradonna, F., Carnevali, O. (2020) Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system. Environmental pollution (Barking, Essex : 1987). 264:114710
- Han, S.L., Liu, Y., Limbu, S.M., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2020) The reduction of lipid-sourced energy production caused by ATGL inhibition cannot be compensated by activation of HSL, autophagy, and utilization of other nutrients in fish. Fish physiology and biochemistry. 47(1):173-188
- Pereiro, P., Librán-Pérez, M., Figueras, A., Novoa, B. (2020) Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator. Developmental and comparative immunology. 109:103698
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