Gene

abat

ID
ZDB-GENE-031006-4
Name
4-aminobutyrate aminotransferase
Symbol
abat Nomenclature History
Previous Names
  • GABA-T (1)
  • cb880 (1)
  • fj82a01
  • wu:fj82a01 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have 4-aminobutyrate transaminase activity and pyridoxal phosphate binding activity. Predicted to be involved in gamma-aminobutyric acid catabolic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Is expressed in blood; liver; nervous system; pronephric duct; and yolk syncytial layer. Orthologous to human ABAT (4-aminobutyrate aminotransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With abat Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
GABA aminotransferase deficiency Alliance GABA-transaminase deficiency 613163
Associated With abat Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR004631 4-aminobutyrate aminotransferase, eukaryotic
Family IPR005814 Aminotransferase class-III
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015422 Pyridoxal phosphate-dependent transferase domain 1
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length 4-aminobutyrate aminotransferase, eukaryotic Aminotransferase class-III Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase domain 1 Pyridoxal phosphate-dependent transferase, major domain
UniProtKB:Q7ZVS4 408
UniProtKB:I3IRW7 500
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations