Gene
gstt1a
- ID
- ZDB-GENE-031001-13
- Name
- glutathione S-transferase theta 1a
- Symbol
- gstt1a Nomenclature History
- Previous Names
-
- gstt1
- cb870 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; eye; intestinal bulb primordium; optic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including GSTT1 (glutathione S-transferase theta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb870 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004045 | Glutathione S-transferase, N-terminal |
| Domain | IPR004046 | Glutathione S-transferase, C-terminal |
| Domain | IPR010987 | Glutathione S-transferase, C-terminal-like |
| Domain | IPR040075 | Glutathione S-transferase Theta, N-terminal |
| Domain | IPR040077 | Glutathione S-transferase Theta, C-terminal |
| Family | IPR051369 | Glutathione S-transferase Theta |
| Homologous_superfamily | IPR036249 | Thioredoxin-like superfamily |
| Homologous_superfamily | IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione S-transferase, C-terminal | Glutathione S-transferase, C-terminal domain superfamily | Glutathione S-transferase, C-terminal-like | Glutathione S-transferase, N-terminal | Glutathione S-transferase Theta | Glutathione S-transferase Theta, C-terminal | Glutathione S-transferase Theta, N-terminal | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7EZ94 | InterPro | 242 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gstt1a-201
(1)
|
Ensembl | 1,047 nt | ||
| mRNA |
gstt1a-202
(1)
|
Ensembl | 1,497 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-42D10 | ||
| Encodes | EST | cb870 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327762 (1) | 920 nt | ||
| Genomic | GenBank:BX640478 (1) | 191201 nt | ||
| Polypeptide | UniProtKB:E7EZ94 (1) | 242 aa |
- Ulhaq, Z.S., Tse, W.K.F. (2024) Transcriptomic analysis reveals mitochondrial dysfunction in the pathogenesis of Nager syndrome in sf3b4-depleted zebrafish. Biochimica et biophysica acta. Molecular basis of disease. 1870(4):167128
- Tierbach, A., Groh, K.J., Schoenenberger, R., Schirmer, K., Suter, M.J. (2020) Biotransformation capacity of zebrafish (Danio rerio) early life stages: Functionality of the mercapturic acid pathway. Toxicological sciences : an official journal of the Society of Toxicology. 176(2):355-365
- Mihaljević, I., Bašica, B., Maraković, N., Kovačević, R., Smital, T. (2019) Interaction of organotin compounds with three major glutathione S-transferases in zebrafish. Toxicology in vitro : an international journal published in association with BIBRA. 62:104713
- Tierbach, A., Groh, K.J., Schönenberger, R., Schirmer, K., Suter, M.J. (2018) Glutathione S-transferase protein expression in different life stages of zebrafish (Danio rerio). Toxicological sciences : an official journal of the Society of Toxicology. 162(2):702-712
- Abunnaja, M.S., Kurogi, K., Mohammed, Y.I., Sakakibara, Y., Suiko, M., Hassoun, E.A., Liu, M.C. (2017) Identification and characterization of the zebrafish glutathione S-transferase Pi-1. Journal of biochemical and molecular toxicology. 31(10)
- Carmona-Antoñanzas, G., Santi, M., Migaud, H., Vera, L.M. (2017) Light- and clock-control of genes involved in detoxification. Chronobiology International. 34(8):1026-1041
- Glisic, B., Mihaljevic, I., Popovic, M., Zaja, R., Loncar, J., Fent, K., Kovacevic, R., Smital, T. (2015) Characterization of glutathione-S-transferases in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 158C:50-62
- Huang, Y., Linsen, S.E. (2015) Partial depletion of yolk during zebrafish embryogenesis changes the dynamics of methionine cycle and metabolic genes. BMC Genomics. 16:427
- Nolte, H., Konzer, A., Ruhs, A., Jungblut, B., Braun, T., Krüger, M. (2014) Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes. Journal of Proteome Research. 13:2162-74
- Yang, F., Xiong, J., Jia, X.E., Gu, Z.H., Shi, J.Y., Zhao, Y., Li, J.M., Chen, S.J., Zhao, W.L. (2014) GSTT1 deletion is related to polycyclic aromatic hydrocarbons-induced DNA damage and lymphoma progression. PLoS One. 9:e89302
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