Gene

siah2l

ID

ZDB-GENE-030922-1

Name

seven in absentia homolog 2 (Drosophila)-like

Symbol

siah2l Nomenclature History

Previous Names

siaz (1)
zgc:66284

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of circadian rhythm. Predicted to act upstream of or within rhythmic process. Predicted to be active in cytoplasm. Is expressed in several structures, including dorsal aorta; male organism; nervous system; optic fissure; and otic vesicle. Orthologous to human SIAH2 (siah E3 ubiquitin protein ligase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66284 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With siah2l Human Ortholog

No data available

Associated With siah2l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR013010	Zinc finger, SIAH-type
Domain	IPR018121	Seven-in-absentia protein, TRAF-like domain
Domain	IPR049548	E3 ubiquitin-protein ligase Sina-like, RING finger
Family	IPR004162	E3 ubiquitin-protein ligase SINA-like, animal
Homologous_superfamily	IPR008974	TRAF-like
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type