Gene
pdgfaa
- ID
- ZDB-GENE-030918-2
- Name
- platelet-derived growth factor alpha polypeptide a
- Symbol
- pdgfaa Nomenclature History
- Previous Names
-
- pdgfa
- Platelet-derived growth factor A (1)
- zgc:100777
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable platelet-derived growth factor receptor binding activity. Involved in angiogenesis. Acts upstream of or within with a positive effect on neural crest cell migration. Acts upstream of or within cardiac muscle progenitor cell migration to the midline involved in heart field formation. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including anterior neural keel; chordo neural hinge; diencephalon; endoderm; and head. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu754 (15 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site | Platelet-derived growth factor, N-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:A5PMP7 | InterPro | 194 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pdgfaa-202
(1)
|
Ensembl | 1,464 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
- Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):
- Murayama, E., Vivier, C., Schmidt, A., Herbomel, P. (2023) Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis. Nature communications. 14:11711171
- Zhao, Y., Wang, H., He, T., Ma, B., Chen, G., Tzeng, C. (2023) Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals. Journal of cell communication and signaling. 17(4):1335-1354
- Owen, N., Toms, M., Young, R.M., Eintracht, J., Sarkar, H., Brooks, B.P., Moosajee, M., Genomics England Research Consortium (2022) Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Genetics in medicine : official journal of the American College of Medical Genetics. 24(5):1073-1084
- Das, T., Soren, K., Yerasi, M., Kamle, A., Kumar, A., Chakravarty, S. (2020) Molecular Basis of Sex Difference in Neuroprotection induced by Hypoxia Preconditioning in Zebrafish. Molecular neurobiology. 57(12):5177-5192
- Lee, Y.H., Kawakami, K., HuangFu, W.C., Liu, I.H. (2020) Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/planar cell polarity pathway. PLoS One. 15:e0230943
- Liu, L., Yu, F., Li, L., Zhou, L., Zhou, T., Xu, Y., Lin, K., Fang, B., Xia, L. (2020) Bone marrow stromal cells stimulated by strontium-substituted calcium silicate ceramics: release of exosomal miR-146a regulates osteogenesis and angiogenesis. Acta biomaterialia. 119:444-457
- Saito, Y., Yamaguchi, A., Nakamura, S., Okuyoshi, H., Shimazawa, M., Hara, H. (2020) Contribution of platelet-derived growth factor signaling to retina regeneration in zebrafish. Neuroscience letters. 727:134930
- Tsata, V., Möllmert, S., Schweitzer, C., Kolb, J., Möckel, C., Böhm, B., Rosso, G., Lange, C., Lesche, M., Hammer, J., Kesavan, G., Beis, D., Guck, J., Brand, M., Wehner, D. (2020) A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord. Developmental Cell. 56(4):509-524.e9
- Li, L., Ning, G., Yang, S., Yan, Y., Cao, Y., Wang, Q. (2019) BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish. PLoS Genetics. 15:e1007996
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