Gene
rdh1
- ID
- ZDB-GENE-030912-15
- Name
- retinol dehydrogenase 1
- Symbol
- rdh1 Nomenclature History
- Previous Names
-
- RDHB (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within several processes, including embryonic pectoral fin morphogenesis; exocrine pancreas development; and retinoid metabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in intestinal bulb and liver. Orthologous to human HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56342 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016625Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027054Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa7214 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34767 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NAD(P)-binding domain superfamily | Short-chain dehydrogenase/reductase SDR |
|---|---|---|---|---|
| UniProtKB:Q7ZUX4 | InterPro | 327 | ||
| UniProtKB:A0A286Y8B5 | InterPro | 327 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-121K8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56342 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198069 (1) | 1170 nt | ||
| Genomic | GenBank:BX927361 (1) | 119117 nt | ||
| Polypeptide | UniProtKB:A0A286Y8B5 (1) | 327 aa |
No data available
- Marqueño, A., Flores, C., Casado, M., Porte, C. (2021) Dysregulation of lipid metabolism in PLHC-1 and ZFL cells exposed to tributyltin an all-trans retinoic acid. Aquatic toxicology (Amsterdam, Netherlands). 231:105733
- Hu, C., Tang, L., Liu, M., Lam, P.K.S., Lam, J.C.W., Chen, L. (2020) Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: Disturbances in retinoid metabolism and visual physiology. Chemosphere. 258:127409
- van der Ven, L.T.M., Schoonen, W.G., Groot, R.M., den Ouden, F., Heusinkveld, H.J., Zwart, E.P., Hodemaekers, H.M., Rorije, E., de Knecht, J. (2020) The effects of aliphatic alcohols and related acid metabolites in zebrafish embryos - correlations with rat developmental toxicity and with effects in advanced life stages in fish. Toxicology and applied pharmacology. 407:115249
- Xiao, Y., Jiang, J., Hu, W., Zhao, Y., Hu, J. (2017) Toxicity of triphenyltin on the development of retinal axons in zebrafish at low dose. Aquatic toxicology (Amsterdam, Netherlands). 189:9-15
- Gebauer, J.M., Kobbe, B., Paulsson, M., Wagener, R. (2016) Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Matrix biology : journal of the International Society for Matrix Biology. 49:106-19
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mesquita, S.R., van Drooge, B.L., Oliveira, E., Grimalt, J.O., Barata, C., Vieira, N., Guimarães, L., Piña, B. (2015) Differential embryotoxicity of the organic pollutants in rural and urban air particles. Environmental pollution (Barking, Essex : 1987). 206:535-542
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Xu, T., Chen, L., Hu, C., and Zhou, B. (2013) Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae. Environmental Toxicology and Pharmacology. 35(1):13-20
- Wang, Y., and Zhang, S. (2011) Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and "pre-hepatic" acute phase response. Functional & integrative genomics. 11(1):111-118
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