Gene

hnrnpa1b

ID

ZDB-GENE-030912-14

Name

heterogeneous nuclear ribonucleoprotein A1b

Symbol

hnrnpa1b Nomenclature History

Previous Names

hnrnpa1
hnrpa1 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have mRNA binding activity. Predicted to be involved in regulation of RNA metabolic process. Predicted to localize to nucleus and ribonucleoprotein complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to human HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6909113 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hnrnpa1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
amyotrophic lateral sclerosis type 20	Alliance	Amyotrophic lateral sclerosis 20	615426
distal myopathy 3	Alliance	?Myopathy, distal, 3	610099
inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3	Alliance	?Inclusion body myopathy with early-onset Paget disease without frontotemporal dementia 3	615424

Associated With hnrnpa1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR034845	hnRNP A1, RNA recognition motif 1
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	hnRNP A1, RNA recognition motif 1	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding domain superfamily	RNA recognition motif domain
UniProtKB:Q803K3 InterPro	422

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	hnrnpa1b-202 (1) Ensembl	Ensembl	1,005 nt	Select Tool
mRNA	hnrnpa1b-201 (1) Ensembl	Ensembl	1,564 nt	Select Tool
mRNA	hnrnpa1b-203 (1) Ensembl	Ensembl	620 nt	Select Tool
mRNA	hnrnpa1b-204 (1) Ensembl	Ensembl	473 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations