Gene

atrx

ID
ZDB-GENE-030912-11
Name
ATRX chromatin remodeler
Symbol
atrx Nomenclature History
Previous Names
  • wu:fb26e12
  • wu:fb52h08
  • wu:fb72g09
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and metal ion binding activity. Human ortholog(s) of this gene implicated in alpha thalassemia-X-linked intellectual disability syndrome and malignant glioma. Orthologous to human ATRX (ATRX chromatin remodeler).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Oppel et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atrx Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alpha thalassemia-X-linked intellectual disability syndrome Alliance Alpha-thalassemia/mental retardation syndrome 301040
alpha-thalassemia myelodysplasia syndrome Alliance Alpha-thalassemia myelodysplasia syndrome, somatic 300448
Intellectual disability-hypotonic facies syndrome, X-linked 309580
Associated With atrx Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000330 SNF2, N-terminal
Domain IPR001650 Helicase, C-terminal
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR025766 ADD domain
Domain IPR041430 ATRX, ADD domain
Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR038718 SNF2-like, N-terminal domain superfamily
Domain Details Per Protein
Protein Length ADD domain ATRX, ADD domain Helicase, C-terminal Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase SNF2-like, N-terminal domain superfamily SNF2, N-terminal Zinc finger, FYVE/PHD-type Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A2R8QG02 1965
UniProtKB:Q7ZUS5 995
UniProtKB:Q6PFN1 732
UniProtKB:F1QJ36 2011
UniProtKB:E7F4M2 2013
UniProtKB:F1QQ67 793
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations