Gene
mcm6
- ID
- ZDB-GENE-030909-6
- Name
- minichromosome maintenance complex component 6
- Symbol
- mcm6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded 3'-5' DNA helicase activity. Predicted to be involved in double-strand break repair via break-induced replication and mitotic DNA replication. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in central nervous system; proliferative region; and skeletal muscle. Orthologous to human MCM6 (minichromosome maintenance complex component 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb800 (6 images)
- IMAGE:7140796 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa38542 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lactose intolerance | Alliance | Lactase persistence/nonpersistence | 223100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018525 | Mini-chromosome maintenance, conserved site |
| Domain | IPR001208 | MCM domain |
| Domain | IPR027925 | MCM, N-terminal domain |
| Domain | IPR033762 | MCM OB domain |
| Domain | IPR041024 | Mcm6, C-terminal winged-helix domain |
| Domain | IPR041562 | MCM, AAA-lid domain |
| Family | IPR008049 | DNA replication licensing factor Mcm6 |
| Family | IPR031327 | Mini-chromosome maintenance protein |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA replication licensing factor Mcm6 | Mcm6, C-terminal winged-helix domain | MCM, AAA-lid domain | MCM domain | MCM, N-terminal domain | MCM OB domain | Mini-chromosome maintenance, conserved site | Mini-chromosome maintenance protein | Nucleic acid-binding, OB-fold | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A3KMS0 | InterPro | 830 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-71C20 | ZFIN Curated Data | |
| Encodes | EST | cb800 | Thisse et al., 2001 | |
| Encodes | EST | fb30d05 | ||
| Encodes | EST | fc26f09 | ||
| Encodes | EST | IMAGE:7055439 | ||
| Encodes | EST | IMAGE:7140796 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:158377 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082849 (1) | 3259 nt | ||
| Genomic | GenBank:CU639421 (1) | 105459 nt | ||
| Polypeptide | UniProtKB:A3KMS0 (1) | 830 aa |
- Xing, J., Chen, K., Gao, S., Pousse, M., Ying, Y., Wang, B., Chen, L., Wang, C., Wang, L., Hu, W., Lu, Y., Gilson, E., Ye, J. (2023) Protein phosphatase 2A activators reverse age-related behavioral changes by targeting neural cell senescence. Aging Cell. 22(3):e13780
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Novak, M., Baebler, Š., Žegura, B., Rotter, A., Gajski, G., Gerić, M., Garaj-Vrhovac, V., Bakos, K., Csenki, Z., Kovács, R., Horváth, Á., Gazsi, G., Filipič, M. (2021) Deregulation of whole-transcriptome gene expression in zebrafish (Danio rerio) after chronic exposure to low doses of imatinib mesylate in a complete life cycle study. Chemosphere. 263:128097
- Sun, C.C., Zhou, Z.Q., Chen, Z.L., Zhu, R.K., Yang, D., Peng, X.Y., Zheng, L., Tang, C.F. (2021) Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Biology. 10(8):
- Kuil, L.E., Oosterhof, N., Ferrero, G., Mikulášová, T., Hason, M., Dekker, J., Rovira, M., van der Linde, H.C., van Strien, P.M., de Pater, E., Schaaf, G., Bindels, E.M., Wittamer, V., van Ham, T.J. (2020) Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. eLIFE. 9:
- Meier, M., Grant, J., Dowdle, A., Thomas, A., Gerton, J., Collas, P., O'Sullivan, J.M., Horsfield, J.A. (2017) Cohesin facilitates zygotic genome activation in zebrafish. Development (Cambridge, England). 145(1)
- Yuan, B., Wang, X., Fan, C., You, J., Liu, Y., Weber, J.D., Zhong, H., Zhang, Y. (2016) DHX33 transcriptionally controls genes involved in cell cycle. Molecular and cellular biology. 36(23):2903-2917
- Bednarek, D., González-Rosa, J.M., Guzmán-Martínez, G., Gutiérrez-Gutiérrez, Ó., Aguado, T., Sánchez-Ferrer, C., Marques, I.J., Galardi-Castilla, M., de Diego, I., Gómez, M.J., Cortés, A., Zapata, A., Jiménez-Borreguero, L.J., Mercader, N., Flores, I. (2015) Telomerase Is Essential for Zebrafish Heart Regeneration. Cell Reports. 12(10):1691-703
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Shinya, M., Machiki, D., Henrich, T., Kubota, Y., Takisawa, H., Mimura, S. (2014) Evolutionary diversification of MCM3 genes in Xenopus laevis and Danio rerio. Cell cycle (Georgetown, Tex.). 13:3271-3281
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