Gene

gtpbp1

ID

ZDB-GENE-030909-12

Name

GTP binding protein 1

Symbol

gtpbp1 Nomenclature History

Previous Names

cb858 (1)
wu:fb36e06
wu:fi39g05
zgc:66228

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have translation elongation factor activity. Predicted to be involved in translational elongation. Is expressed in intermediate cell mass of mesoderm; intermediate mesoderm; lens; solid lens vesicle; and ventral mesoderm. Orthologous to human GTPBP1 (GTP binding protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb858 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gtpbp1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with characteristic facial and ectodermal features and tetraparesis 1	620888

Associated With gtpbp1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000795	Translational (tr)-type GTP-binding domain
Domain	IPR004161	Translation elongation factor EFTu-like, domain 2
Domain	IPR035531	GTP binding protein 1-like, GTP-binding domain
Family	IPR050055	Elongation factor Tu GTPase
Homologous_superfamily	IPR009000	Translation protein, beta-barrel domain superfamily
Homologous_superfamily	IPR009001	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	Elongation factor Tu GTPase	GTP binding protein 1-like, GTP-binding domain	P-loop containing nucleoside triphosphate hydrolase	Translational (tr)-type GTP-binding domain	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal	Translation elongation factor EFTu-like, domain 2	Translation protein, beta-barrel domain superfamily
UniProtKB:A0A8M2BB58 InterPro	652
UniProtKB:A0A8M9PEZ2 InterPro	639
UniProtKB:Q6PFN0 InterPro	642
UniProtKB:A0A8M2BBB3 InterPro	670
UniProtKB:A0A8N1TRQ8 InterPro	657