Gene
pde6gb
- ID
- ZDB-GENE-030904-1
- Name
- phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b
- Symbol
- pde6gb Nomenclature History
- Previous Names
-
- pde6g (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable cGMP binding activity; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in positive regulation of G protein-coupled receptor signaling pathway and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to act upstream of or within visual perception. Predicted to be active in photoreceptor outer segment membrane. Is expressed in epidermis; epiphysis; retina; and retinal rod cell. Human ortholog(s) of this gene implicated in retinitis pigmentosa 57. Orthologous to human PDE6G (phosphodiesterase 6G).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55991 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 57 | Alliance | Retinitis pigmentosa 57 | 613582 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Retinal cGMP phosphodiesterase, gamma subunit | Retinal cGMP phosphodiesterase, gamma subunit superfamily |
|---|---|---|---|---|
| UniProtKB:Q7ZVI5 | InterPro | 87 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pde6gb-201
(1)
|
Ensembl | 1,711 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-113D16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55991 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77811 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173941 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191606 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212799 (1) | 1769 nt | ||
| Genomic | GenBank:AL954682 (1) | 181276 nt | ||
| Polypeptide | UniProtKB:Q7ZVI5 (1) | 87 aa |
- Wu, Y., Liu, W., Li, L., Tai, Z., Gao, B., Liu, J.X. (2023) Atp7b deficiency induces zebrafish eye developmental defects. Metallomics : integrated biometal science. 15(5):
- Abalo, X.M., Lagman, D., Heras, G., Del Pozo, A., Eggert, J., Larhammar, D. (2019) Circadian regulation of phosphodiesterase 6 genes in zebrafish differs between cones and rods: Implications for photopic and scotopic vision. Vision Research. 166:43-51
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Feng, D., Chen, Z., Yang, K., Miao, S., Xu, B., Kang, Y., Xie, H., Zhao, C. (2017) The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants. The Journal of biological chemistry. 292(42):17375-17386
- Lagman, D., Franzén, I.E., Eggert, J., Larhammar, D., Abalo, X.M. (2016) Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. BMC Evolutionary Biology. 16:124
- Laranjeiro, R., Whitmore, D. (2014) Transcription factors involved in retinogenesis are co-opted by the circadian clock following photoreceptor differentiation. Development (Cambridge, England). 141(13):2644-56
- Viringipurampeer, I.A., Shan, X., Gregory-Evans, K., Zhang, J.P., Mohammadi, Z., and Gregory-Evans, C.Y. (2014) Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish. Cell death and differentiation. 21(11):1320-9
- O'Quin, K.E., Yoshizawa, M., Doshi, P., and Jeffery, W.R. (2013) Quantitative Genetic Analysis of Retinal Degeneration in the Blind Cavefish Astyanax mexicanus. PLoS One. 8(2):e57281
- Vihtelic, T.S., Fadool, J.M., Gao, J., Thornton, K.A., Hyde, D.R., and Wistow, G. (2005) Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Molecular Vision. 11:1083-1100
- Brockerhoff, S.E., Rieke, F., Matthews, H.R., Taylor, M.R., Kennedy, B., Ankoudinova, I., Niemi, G.A., Tucker, C.L., Xiao, M., Cilluffo, M.C., Fain, G.L., and Hurley, J.B. (2003) Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(2):470-480
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