ZFIN is now using GRCz12tu for Genomic Data
Gene
cdk8
- ID
- ZDB-GENE-030903-2
- Name
- cyclin dependent kinase 8
- Symbol
- cdk8 Nomenclature History
- Previous Names
-
- wu:fk95h11
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle and regulation of transcription by RNA polymerase II. Predicted to be part of CKM complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CDK8 (cyclin dependent kinase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147230 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder with hypotonia and behavioral abnormalities | 618748 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclin-dependent kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:A8E4S2 | InterPro | 465 | |||||
| UniProtKB:Q8JH47 | InterPro | 464 | |||||
| UniProtKB:A0A8M2B9W5 | InterPro | 468 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers