Gene
slc12a7b
- ID
- ZDB-GENE-030829-61
- Name
- solute carrier family 12 member 7b
- Symbol
- slc12a7b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to act upstream of or within potassium ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cranial ganglion; fin; myotome; neural tube; and sensory system. Orthologous to human SLC12A7 (solute carrier family 12 member 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb734 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17478 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24562 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24563 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24564 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24565 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37961 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Amino acid permease/ SLC12A domain | K/Cl co-transporter | SLC12A transporter, C-terminal | SLC12A transporter family |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B9W9 | InterPro | 1096 | ||||
| UniProtKB:A0A8M2B9W4 | InterPro | 1133 | ||||
| UniProtKB:A0A8M2B9Y8 | InterPro | 1094 | ||||
| UniProtKB:A0A8N7TBP4 | InterPro | 1119 | ||||
| UniProtKB:A0A8M2BA74 | InterPro | 1101 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc12a7b-201
(1)
|
Ensembl | 3,147 nt | ||
| mRNA |
slc12a7b-202
(1)
|
Ensembl | 4,479 nt | ||
| ncRNA |
slc12a7b-002
(1)
|
Ensembl | 738 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-276F18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-286C5 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-106G6 | ZFIN Curated Data | |
| Encodes | EST | cb734 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005162910 (1) | 4439 nt | ||
| Genomic | GenBank:BX323854 (2) | 161864 nt | ||
| Polypeptide | UniProtKB:A0A8M2BA14 (1) | 1138 aa |
- Lanni, J.S., Peal, D., Ekstrom, L., Chen, H., Stanclift, C., Bowen, M.E., Mercado, A., Gamba, G., Kahle, K.T., Harris, M.P. (2019) Integrated K+ channel and K+Cl- cotransporter function are required for the coordination of size and proportion during development. Developmental Biology. 456(2):164-178
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Matos-Cruz, V., Blasic, J., Nickle, B., Robinson, P.R., Hattar, S., and Halpern, M.E. (2011) Unexpected diversity and photoperiod dependence of the zebrafish melanopsin system. PLoS One. 6(9):e25111
- Pujic, Z., Omori, Y., Tsujikawa, M., Thisse, B., Thisse, C., and Malicki, J. (2006) Reverse genetic analysis of neurogenesis in the zebrafish retina. Developmental Biology. 293(2):330-347
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