Gene

bub1bb

ID
ZDB-GENE-030829-51
Name
BUB1 mitotic checkpoint serine/threonine kinase Bb
Symbol
bub1bb Nomenclature History
Previous Names
  • sb:cb730
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable kinase activity. Predicted to act upstream of or within mitotic spindle assembly checkpoint signaling and phosphorylation. Is expressed in hindbrain; optic tectum; pectoral fin musculature; proliferative region; and retina. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2001
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bub1bb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
colorectal cancer Alliance Colorectal cancer, somatic 114500
mosaic variegated aneuploidy syndrome 1 Alliance Mosaic variegated aneuploidy syndrome 1 257300
[Premature chromatid separation trait] 176430
1 - 3 of 3
Associated With bub1bb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013212 Mad3/Bub1 homology region 1
Family IPR015661 Mitotic spindle checkpoint protein Bub1/Mad3
1 - 2 of 2
Domain Details Per Protein
Protein Additional Resources Length Mad3/Bub1 homology region 1 Mitotic spindle checkpoint protein Bub1/Mad3
UniProtKB:E7F5T9 InterPro 427
1 - 1 of 1
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA bub1bb-201 (1) Ensembl 5,991 nt
mRNA bub1bb-202 (1) Ensembl 6,078 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations