Gene
ppp3cca
- ID
- ZDB-GENE-030829-36
- Name
- protein phosphatase 3, catalytic subunit, gamma isozyme, a
- Symbol
- ppp3cca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-mediated signaling. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including hatching gland; musculature system; nervous system; polster; and trigeminal placode. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb767 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16822 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20428 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33612 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45205 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Metallo-dependent phosphatase-like | PP2B | PP2B, metallophosphatase domain | Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase |
|---|---|---|---|---|---|---|
| UniProtKB:A3KGZ6 | InterPro | 499 | ||||
| UniProtKB:A0A286YA34 | InterPro | 508 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppp3cca-201
(1)
|
Ensembl | 2,887 nt | ||
| mRNA |
ppp3cca-202
(1)
|
Ensembl | 1,527 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:EGFP-2A-cappp3cca) |
| 1 | Massoz et al., 2024 | ||
| Tg(UAS:EGFP-2A-cappp3cca) |
| 1 | Massoz et al., 2024 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-133N22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-21K4 | ZFIN Curated Data | |
| Contains | STS | chunp30215 | Geisler et al., 1999 | |
| Encodes | EST | cb767 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001166628 (1) | 2459 nt | ||
| Genomic | GenBank:BX666060 (1) | 180348 nt | ||
| Polypeptide | UniProtKB:A0A286YA34 (1) | 508 aa |
- Massoz, L., Bergemann, D., Lavergne, A., Reynders, C., Désiront, C., Goossens, C., Flasse, L., Peers, B., Voz, M.M., Manfroid, I. (2024) Negative cell cycle regulation by calcineurin is necessary for proper beta cell regeneration in zebrafish. eLIFE. 12:
- Cao, S., Dong, Z., Dong, X., Jia, W., Zhou, F., Zhao, Q. (2023) Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior. Zebrafish. 20:101810-18
- Lu, Y., Tang, D., Zheng, Z., Wang, X., Zuo, N., Yan, R., Wu, C., Ma, J., Wang, C., Xu, H., He, Y., Liu, D., Liu, S. (2022) Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Frontiers in molecular neuroscience. 15:844668
- Sojan, J.M., Gundappa, M.K., Carletti, A., Gaspar, V., Gavaia, P., Maradonna, F., Carnevali, O. (2022) Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism. Frontiers in nutrition. 9:868805
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
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