ZFIN is now using GRCz12tu for Genomic Data
Gene
map3k5
- ID
- ZDB-GENE-030827-3
- Name
- mitogen-activated protein kinase kinase kinase 5
- Symbol
- map3k5 Nomenclature History
- Previous Names
-
- Ask1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable MAP kinase kinase kinase activity. Acts upstream of or within defense response to bacterium. Is expressed in cranium. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu797 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR025136 | MAP3K, TRAFs-binding domain |
| Domain | IPR043969 | MAP3K, PH domain |
| Domain | IPR046872 | MAP3K, deoxyribohydrolase domain |
| Domain | IPR046873 | MAP3K, HisK-N-like globin domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | MAP3K, deoxyribohydrolase domain | MAP3K, HisK-N-like globin domain | MAP3K, PH domain | MAP3K, TRAFs-binding domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F2L3 | InterPro | 1364 | |||||||||
| UniProtKB:A0A8M9P2K6 | InterPro | 1356 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map3k5-201
(1)
|
Ensembl | 4,095 nt | ||
| mRNA |
map3k5-204
(1)
|
Ensembl | 5,774 nt | ||
| ncRNA |
map3k5-002
(1)
|
Ensembl | 730 nt | ||
| ncRNA |
map3k5-003
(1)
|
Ensembl | 930 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers