Gene

hdr

ID
ZDB-GENE-030826-5
Name
hematopoietic death receptor
Symbol
hdr Nomenclature History
Previous Names
  • zgc:103531
  • ZH-DR
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Involved in TRAIL-activated apoptotic signaling pathway. Acts upstream of or within positive regulation of apoptotic process and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in plasma membrane. Is expressed in axis; hematopoietic system; mesoderm; and notochord. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including TNFRSF10A (TNF receptor superfamily member 10a) and TNFRSF10B (TNF receptor superfamily member 10b).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hdr Human Ortholog
No data available
Associated With hdr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000488 Death domain
Domain IPR001368 TNFR/NGFR cysteine-rich region
Domain IPR034024 Tumor necrosis factor receptor 10, N-terminal
Domain IPR034029 Tumour necrosis factor receptor 10A/B, death domain
Homologous_superfamily IPR011029 Death-like domain superfamily
Domain Details Per Protein
Protein Length Death domain Death-like domain superfamily TNFR/NGFR cysteine-rich region Tumor necrosis factor receptor 10, N-terminal Tumour necrosis factor receptor 10A/B, death domain
UniProtKB:Q9DF34 357
UniProtKB:F1QD95 418
UniProtKB:A3KPR7 357
UniProtKB:Q5U3H1 418
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations