ZFIN is now using GRCz12tu for Genomic Data
Gene
tpm3
- ID
- ZDB-GENE-030826-16
- Name
- tropomyosin 3
- Symbol
- tpm3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable actin filament binding activity. Acts upstream of or within skeletal myofibril assembly. Predicted to be located in cytoskeleton. Predicted to be active in actin filament. Is expressed in several structures, including adaxial cell; alar plate midbrain region; axis; brain; and musculature system. Human ortholog(s) of this gene implicated in congenital myopathy 4A and congenital myopathy 4B. Orthologous to human TPM3 (tropomyosin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77592 (21 images)
- cb674 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Bonnet et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital myopathy 4A | Alliance | Congenital myopathy 4A, autosomal dominant | 255310 |
| congenital myopathy 4B | Alliance | Congenital myopathy 4B, autosomal recessive | 609284 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA repair protein XRCC4-like, C-terminal | Tropomyosin |
|---|---|---|---|---|
| UniProtKB:A0A8M2B6C5 | InterPro | 248 | ||
| UniProtKB:A0A8M2B602 | InterPro | 284 | ||
| UniProtKB:A0A2R8Q650 | InterPro | 284 | ||
| UniProtKB:A0A8M2B695 | InterPro | 248 | ||
| UniProtKB:I3ISQ1 | InterPro | 284 | ||
| UniProtKB:Q6P0W3 | InterPro | 284 | ||
| UniProtKB:Q803M1 | InterPro | 248 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers