Gene

tpm3

ID

ZDB-GENE-030826-16

Name

tropomyosin 3

Symbol

tpm3 Nomenclature History

Previous Names

cb674 (1)
fa17b11
fb83b01
fk41e01
hm:zeh0298 (1)
wu:fa17b11 (1)
wu:fb83b01 (1)
wu:fk41e01 (1)
zeh0298
zgc:77592

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity. Involved in skeletal myofibril assembly. Predicted to localize to actin filament. Is expressed in several structures, including adaxial cell; alar plate midbrain region; axis; brain; and musculature system. Human ortholog(s) of this gene implicated in congenital fiber-type disproportion and nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

28 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77592 (21 images)
cb674 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Bonnet et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tpm3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital myopathy 4A	Alliance	Congenital myopathy 4A, autosomal dominant	255310
nemaline myopathy 1	Alliance	Congenital myopathy 4B, autosomal recessive	609284

Associated With tpm3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000533	Tropomyosin
Homologous_superfamily	IPR014751	DNA repair protein XRCC4-like, C-terminal

Domain Details Per Protein

Protein	Length	DNA repair protein XRCC4-like, C-terminal	Tropomyosin
UniProtKB:A0A8M2B6C5 InterPro	248
UniProtKB:A0A8M2B602 InterPro	284
UniProtKB:A0A2R8Q650 InterPro	284
UniProtKB:A0A8M2B695 InterPro	248
UniProtKB:I3ISQ1 InterPro	284
UniProtKB:Q6P0W3 InterPro	284
UniProtKB:Q803M1 InterPro	248

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tpm3-201 (1) Ensembl	Havana	2501 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpm3-202 (1) Ensembl	Havana	1496 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpm3-203 (1) Ensembl	Havana	386 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpm3-204 (1) Ensembl	Havana	3093 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tpm3-205 (1) Ensembl	Ensembl	5073 nt	Select Tool ZFIN BLAST
mRNA	tpm3-206 (1) Ensembl	Ensembl	5591 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations