Gene

aifm1

ID
ZDB-GENE-030826-11
Name
apoptosis inducing factor mitochondrion associated 1
Symbol
aifm1 Nomenclature History
Previous Names
  • AIF
  • pdcd8
  • zgc:91994
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have flavin adenine dinucleotide binding activity; oxidoreductase activity; and protein dimerization activity. Predicted to be involved in apoptotic process and oxidation-reduction process. Predicted to localize to integral component of membrane and mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; hatching gland; musculature system; and polster. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With aifm1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Combined oxidative phosphorylation deficiency 6 300816
Cowchock syndrome 310490
Deafness, X-linked 5 300614
Spondyloepimetaphyseal dysplasia, X-linked, with hypomyelinating leukodystrophy 300232
Associated With aifm1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR023753 FAD/NAD(P)-binding domain
Domain IPR029324 Mitochondrial apoptosis-inducing factor, C-terminal domain
Domain IPR032773 Protein MGARP, N-terminal
Homologous_superfamily IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamily
Homologous_superfamily IPR036188 FAD/NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length FAD/NAD-linked reductase, dimerisation domain superfamily FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain superfamily Mitochondrial apoptosis-inducing factor, C-terminal domain Protein MGARP, N-terminal
UniProtKB:A0A8M2BCB6 748
UniProtKB:Q5XFY2 613
UniProtKB:A0A8M3AS24 621
UniProtKB:A0A8M2BCF4 740
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations