Gene
birc2
- ID
- ZDB-GENE-030825-6
- Name
- baculoviral IAP repeat containing 2
- Symbol
- birc2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of programmed cell death; positive regulation of protein ubiquitination; and regulation of cell cycle. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be active in cytoplasm and nucleus. Is expressed in dorsal aorta; intersegmental vessel; and posterior cardinal vein. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Orthologous to several human genes including BIRC2 (baculoviral IAP repeat containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903716 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2026aTg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la021887Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| s805 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001315 | CARD domain |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR041933 | BIRC2/BIRC3, UBA domain |
| Domain | IPR048875 | BIRC2/3-like, UBA domain |
| Family | IPR050784 | Inhibitor of Apoptosis |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Repeat | IPR001370 | BIR repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | BIRC2/3-like, UBA domain | BIRC2/BIRC3, UBA domain | BIR repeat | CARD domain | Death-like domain superfamily | Inhibitor of Apoptosis | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QDZ3 | InterPro | 633 | ||||||||
| UniProtKB:Q7T0K2 | InterPro | 647 | ||||||||
| UniProtKB:Q8UWD2 | InterPro | 628 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-59N7 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-69C1 | Santoro et al., 2007 | |
| Contained in | BAC | RP71-1P14 | ||
| Encodes | EST | IMAGE:6903716 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:136721 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152673 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193097 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194395 (1) | 2602 nt | ||
| Genomic | GenBank:BX510940 | 172605 nt | ||
| Polypeptide | UniProtKB:Q7T0K2 (1) | 647 aa |
- Cao, L., Yan, D., Xiao, J., Feng, H., Chang, M.X. (2021) The Zebrafish Antiapoptotic Protein BIRC2 Promotes Edwardsiella piscicida Infection by Inhibiting Caspases and Accumulating p53 in a p53 Transcription-Dependent and -Independent Manner. Frontiers in immunology. 12:781680
- Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
- Vázquez-Marín, J., Gutiérrez-Triana, J.A., Almuedo-Castillo, M., Buono, L., Gómez-Skarmeta, J.L., Mateo, J.L., Wittbrodt, J., Martínez-Morales, J.R. (2019) Yap1b, a divergent Yap/Taz family member, cooperates with yap1 in survival and morphogenesis via common transcriptional targets. Development (Cambridge, England). 146(13):
- Dai, Y., Prithiviraj, N., Gan, J., Zhang, X.A., Yan, J. (2016) Tissue Extract Fractions from Starfish Undergoing Regeneration Promote Wound Healing and Lower Jaw Blastema Regeneration of Zebrafish. Scientific Reports. 6:38693
- Hu, P., Liu, M., Liu, Y., Wang, J., Zhang, D., Niu, H., Jiang, S., Wang, J., Zhang, D., Han, B., Xu, Q., Chen, L. (2016) Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Scientific Reports. 6:28952
- Zhou, Z.J., Sun, L. (2016) Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Frontiers in cellular and infection microbiology. 6:76
- Essers, P.B., Klasson, T.D., Pereboom, T.C., Mans, D.A., Nicastro, M., Boldt, K., Giles, R.H., and MacInnes, A.W. (2015) The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2. Oncogene. 146(3):789-800.e8
- Fukui, H., Terai, K., Nakajima, H., Chiba, A., Fukuhara, S., Mochizuki, N. (2014) S1P-Yap1 Signaling Regulates Endoderm Formation Required for Cardiac Precursor Cell Migration in Zebrafish. Developmental Cell. 31:128-136
- Goncharov, T., Niessen, K., de Almagro, M.C., Izrael-Tomasevic, A., Fedorova, A.V., Varfolomeev, E., Arnott, D., Deshayes, K., Kirkpatrick, D.S., and Vucic, D. (2013) OTUB1 modulates c-IAP1 stability to regulate signalling pathways. The EMBO journal. 32(8):1103-14
- Hu, J., Sun, S., Jiang, Q., Sun, S., Wang, W., Gui, Y., and Song, H. (2013) Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). International journal of biological sciences. 9(3):267-278
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