Gene
tp73
- ID
- ZDB-GENE-030814-2
- Name
- tumor protein p73
- Symbol
- tp73 Nomenclature History
- Previous Names
-
- TAp73 (1)
- sb:eu652
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity. Acts upstream of or within embryonic cranial skeleton morphogenesis and regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including gonad; musculature system; nervous system; pharynx; and renal system. Human ortholog(s) of this gene implicated in several diseases, including Epstein-Barr virus infectious disease; cervical cancer; colorectal cancer; kidney cancer (multiple); and lung cancer (multiple). Orthologous to human TP73 (tumor protein p73).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu652 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ciliary dyskinesia, primary, 47, and lissencephaly | 619466 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR010991 | p53, tetramerisation domain |
| Domain | IPR011615 | p53, DNA-binding domain |
| Family | IPR002117 | p53 tumour suppressor family |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012346 | p53/RUNT-type transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036674 | p53-like tetramerisation domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | p53, DNA-binding domain | p53-like tetramerisation domain superfamily | p53-like transcription factor, DNA-binding domain superfamily | p53/RUNT-type transcription factor, DNA-binding domain superfamily | p53, tetramerisation domain | p53 tumour suppressor family | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q801Z7 | InterPro | 640 | ||||||||
| UniProtKB:B0S576 | InterPro | 640 | ||||||||
| UniProtKB:A0A8M3AVI5 | InterPro | 585 | ||||||||
| UniProtKB:B0S577 | InterPro | 555 |
Interactions and Pathways
No data available
Plasmids
No data available