Gene
tp73
- ID
- ZDB-GENE-030814-2
- Name
- tumor protein p73
- Symbol
- tp73 Nomenclature History
- Previous Names
-
- TAp73 (1)
- sb:eu652
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity. Acts upstream of or within embryonic cranial skeleton morphogenesis and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Is expressed in several structures, including gonad; musculature system; nervous system; pharynx; and renal system. Human ortholog(s) of this gene implicated in several diseases, including Epstein-Barr virus infectious disease; cervical cancer; colorectal cancer; kidney cancer (multiple); and lung cancer (multiple). Orthologous to human TP73 (tumor protein p73).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu652 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ciliary dyskinesia, primary, 47, and lissencephaly | 619466 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR010991 | p53, tetramerisation domain |
| Domain | IPR011615 | p53, DNA-binding domain |
| Family | IPR002117 | p53 tumour suppressor family |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012346 | p53/RUNT-type transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036674 | p53-like tetramerisation domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | p53, DNA-binding domain | p53-like tetramerisation domain superfamily | p53-like transcription factor, DNA-binding domain superfamily | p53/RUNT-type transcription factor, DNA-binding domain superfamily | p53, tetramerisation domain | p53 tumour suppressor family | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q801Z7 | InterPro | 640 | ||||||||
| UniProtKB:B0S576 | InterPro | 640 | ||||||||
| UniProtKB:A0A8M3AVI5 | InterPro | 585 | ||||||||
| UniProtKB:B0S577 | InterPro | 555 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available