ZFIN Gene: tp73

ZFIN ID: ZDB-GENE-030814-2

ZFIN ID: ZDB-GENE-030814-2

Gene Name:

tumor protein p73

Gene Symbol:

tp73

Sequence Ontology ID :

SO:0000704

Previous Names:

TAp73 (1), sb:eu652

Location:

Chr: 8 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Exhibits DNA-binding transcription factor activity. Involved in embryonic cranial skeleton morphogenesis and regulation of transcription, DNA-templated. Predicted to localize to the transcription ...

GENE EXPRESSION
All Expression Data:	21 figures from 7 publications
Directly Submitted Expression Data:	6 figures (12 images) from Thisse et al., 2005 [eu652]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
	brain cerebellum diencephalon endoderm eye fin gill granulosa cell layer hindbrain hypothalamus integument kidney midbrain olfactory bulb olfactory epithelium olfactory pit olfactory placode olfactory rosette optic tectum ovarian follicle stage I ovary peripheral olfactory organ pharyngeal arch pharyngeal arch 3-7 skeleton pharyngeal endoderm pharyngeal epithelium pharyngeal pouch presumptive brain primitive olfactory epithelium pronephric duct slow muscle cell spermatocyte spermatogonium telencephalon testis thecal cell layer trunk musculature unspecified whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la016418Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la029503Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:	5 figures from 3 publications
Observed in:	basibranchial basihyal cartilage brain ceratobranchial cartilage ceratohyal cartilage cranial cartilage embryonic cranial skeleton morphogenesis eye head hyosymplectic cartilage inner ear neurogenesis olfactory placode palatoquadrate cartilage pharyngeal arch renal system process splanchnocranium telencephalon telencephalon development whole organism

DISEASE ASSOCIATED WITH tp73 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH tp73 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	regulation of transcription, DNA-templated (more)
Cellular Component	transcription factor complex (more)
Molecular Function	DNA-binding transcription factor activity (more)

GO Terms (all 30)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001660 (1) InterPro:IPR002117 (1) InterPro:IPR008967 (1) InterPro:IPR010991 (1) InterPro:IPR011615 (1) InterPro:IPR012346 (1) InterPro:IPR013761 (1) InterPro:IPR032646 (1) InterPro:IPR036674 (1)	PROSITE:PS00348 (1)	Pfam:PF00870 (1) Pfam:PF07647 (1) Pfam:PF07710 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	tp73-201 (1)	1969	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tp73-203 (1)	2620	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM tp73 No data available

MARKER RELATIONSHIPS

tp73Contained in:	[BAC] CH211-69A12 (1) (order this), CH211-278P7 (1) (order this), DKEY-71C4 (1) (order this)
tp73Encodes:	[EST] eu652 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_183340 (1)	2350bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX323556 (1)	178137bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:B0S576 (1)	640aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:24319 (1)

Sequence Information (all 29)

OTHER tp73 GENE PAGES

Alliance (1)

Gene:368221 (1)

VEGA:OTTDARG00000020487 (1)

Ensembl(GRCz11):ENSDARG00000017953 (1)

ORTHOLOGY for tp73 (Chr: 8)

CITATIONS (36)

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