Gene

tp73

ID
ZDB-GENE-030814-2
Name
tumor protein p73
Symbol
tp73 Nomenclature History
Previous Names
  • TAp73 (1)
  • sb:eu652
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity. Involved in embryonic cranial skeleton morphogenesis and regulation of transcription, DNA-templated. Predicted to localize to transcription regulator complex. Is expressed in several structures, including gonad; musculature system; nervous system; pharynx; and renal system. Human ortholog(s) of this gene implicated in breast cancer; lung cancer; nephroblastoma; and renal cell carcinoma. Orthologous to human TP73 (tumor protein p73).
Genome Resources
Note
None
Expression
All Expression Data
22 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tp73 Human Ortholog
No data available
Associated With tp73 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001660 Sterile alpha motif domain
Domain IPR010991 p53, tetramerisation domain
Domain IPR011615 p53, DNA-binding domain
Family IPR002117 p53 tumour suppressor family
Family IPR032646 Tumour protein p73
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR036674 p53-like tetramerisation domain superfamily
Domain Details Per Protein
Protein Length p53, DNA-binding domain p53-like tetramerisation domain superfamily p53-like transcription factor, DNA-binding p53/RUNT-type transcription factor, DNA-binding domain superfamily p53, tetramerisation domain p53 tumour suppressor family Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily Tumour protein p73
UniProtKB:B0S576 640
UniProtKB:Q6UNX2 640
UniProtKB:B0S577 555
UniProtKB:Q5KQU6 555
UniProtKB:Q801Z7 640
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations