Gene

pdgfrb

ID
ZDB-GENE-030805-2
Name
platelet-derived growth factor receptor, beta polypeptide
Symbol
pdgfrb Nomenclature History
Previous Names
  • pdgfrb2
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable ATP binding activity and transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within animal organ development and vasculature development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including blood vessel; floor plate neural tube; gut; hypochord; and somite. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pdgfrb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
basal ganglia calcification Alliance Basal ganglia calcification, idiopathic, 4 615007
infantile myofibromatosis Alliance Myofibromatosis, infantile, 1 228550
myeloproliferative disorder with eosinophilia Alliance Myeloproliferative disorder with eosinophilia 131440
Kosaki overgrowth syndrome 616592
Premature aging syndrome, Penttinen type 601812
Associated With pdgfrb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class III, conserved site
UniProtKB:A0A0G2L2B8 877
UniProtKB:D9MNA7 1064
UniProtKB:Q8JHY2 63
UniProtKB:A0A2R8QHE8 1072
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pdgfrb polyclonal Rabbit
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations