Gene
lamp2
- ID
- ZDB-GENE-030729-9
- Name
- lysosomal-associated membrane protein 2
- Symbol
- lamp2 Nomenclature History
- Previous Names
-
- sb:cb587
- wu:fb14a06
- zgc:103532
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to be involved in autophagosome maturation; cellular response to starvation; and protein targeting to lysosome involved in chaperone-mediated autophagy. Predicted to localize to bounding membrane of organelle and plasma membrane. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Is expressed in cardiovascular system; heart; solid lens vesicle; vein; and yolk syncytial layer. Orthologous to human LAMP2 (lysosomal associated membrane protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb587 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Dvornikov et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Danon disease | Alliance | Danon disease | 300257 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Danon disease | lamp2xu082/xu082 (WIK) | standard conditions | Dvornikov et al., 2019 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Lysosome-associated membrane glycoprotein | Lysosome-associated membrane glycoprotein 2-like, luminal domains | Lysosome-associated membrane glycoprotein 2-like, transmembrane domain |
|---|---|---|---|---|
|
UniProtKB:Q5BKX3
|
355 | |||
|
UniProtKB:A0A2R8Q0I4
|
358 | |||
|
UniProtKB:A0A0R4IZ00
|
356 |
Interactions and Pathways
No data available
Plasmids
No data available