Gene
slc26a2
- ID
- ZDB-GENE-030717-3
- Name
- solute carrier family 26 member 2
- Symbol
- slc26a2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable inorganic anion transmembrane transporter activity and organic anion transmembrane transporter activity. Acts upstream of or within several processes, including inner ear development; sensory perception of sound; and swimming behavior. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in lateral line primordium; midbrain; otic vesicle; pectoral fin bud; and pronephric duct. Human ortholog(s) of this gene implicated in bone disease (multiple). Orthologous to human SLC26A2 (solute carrier family 26 member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Liu et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| achondrogenesis type IB | Alliance | Achondrogenesis Ib | 600972 |
| atelosteogenesis | Alliance | Atelosteogenesis, type II | 256050 |
| atelosteogenesis | Alliance | De la Chapelle dysplasia | 256050 |
| diastrophic dysplasia | Alliance | Diastrophic dysplasia | 222600 |
| diastrophic dysplasia | Alliance | Diastrophic dysplasia, broad bone-platyspondylic variant | 222600 |
| multiple epiphyseal dysplasia 4 | Alliance | Epiphyseal dysplasia, multiple, 4 | 226900 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | SLC26A/SulP transporter | SLC26A/SulP transporter domain | STAS domain | STAS domain superfamily | Sulphate anion transporter, conserved site |
|---|---|---|---|---|---|---|---|
| UniProtKB:E7F9I7 | InterPro | 699 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc26a2-201
(1)
|
Ensembl | 4,920 nt | ||
| mRNA |
slc26a2-202
(1)
|
Ensembl | 4,690 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-164P4 | ||
| Contained in | BAC | DKEY-280E21 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005173160 (1) | 4718 nt | ||
| Genomic | GenBank:BX511257 (1) | 166973 nt | ||
| Polypeptide | UniProtKB:E7F9I7 (1) | 699 aa |
- Urasaki, A., Morishita, S., Naka, K., Uozumi, M., Abe, K., Huang, L., Watase, E., Nakagawa, O., Kawakami, K., Matsui, T., Bessho, Y., Inagaki, N. (2019) Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system. Scientific Reports. 9:12156
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, F., Xia, W., Hu, J., Wang, Y., Yang, F., Sun, S., Zhang, J., Jiang, N., Wang, H., Tian, W., Wang, X., Ma, D. (2015) Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish. PLoS One. 10:e0136832
- Bayaa, M., Vulesevic, B., Esbaugh, A., Braun, M., Ekker, M.E., Grosell, M., and Perry, S.F. (2009) The involvement of SLC26 anion transporters in chloride uptake in zebrafish (Danio rerio) larvae. The Journal of experimental biology. 212(Pt 20):3283-3295
- Wingert, R.A., Selleck, R., Yu, J., Song, H.D., Chen, Z., Song, A., Zhou, Y., Thisse, B., Thisse, C., McMahon, A.P., and Davidson, A.J. (2007) The cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros. PLoS Genetics. 3(10):1922-1938
- Weber, T., Gopfert, M.C., Winter, H., Zimmerman, U., Kohler, H., Meier, A., Hendrich, O., Rohbock, K., Robert, D., and Knipper, M. (2003) Expression of prestin-homologous solute carrier (SLC26) in auditory organs of nonmammalian vertebrates and insects. Proceedings of the National Academy of Sciences of the United States of America. 100(13):7690-7695
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