Gene
wnt2ba
- ID
- ZDB-GENE-030717-2
- Name
- wingless-type MMTV integration site family, member 2Ba
- Symbol
- wnt2ba Nomenclature History
- Previous Names
-
- wnt2b
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within embryonic pectoral fin morphogenesis; podocyte development; and sensory epithelium regeneration. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in brain; immature eye; mesoderm; and pronephros. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human WNT2B (Wnt family member 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16775 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-wnt2ba | N/A | (2) |
| MO2-wnt2ba | N/A | (2) |
| MO3-wnt2ba | N/A | (2) |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diarrhea 9 | 618168 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Wnt | Wnt-2 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:Q8AY89 | InterPro | 387 | ||||
| UniProtKB:A0A8M3B3N2 | InterPro | 230 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
wnt2ba-201
(1)
|
Ensembl | 1,771 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(UAS:EGFP-wnt2ba) |
|
| 1 | Clark et al., 2021 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-166J19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193521 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193522 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_182876 (1) | 1791 nt | ||
| Genomic | GenBank:CR382321 (1) | 212455 nt | ||
| Polypeptide | UniProtKB:Q8AY89 (1) | 387 aa |
- Xie, J., Bui, B.V., Goodbourn, P.T., Jusuf, P.R. (2024) EFEMP1 contributes to light-dependent ocular growth in zebrafish. Biology Open. 13(12):
- Xie, J., Goodbourn, P.T., Bui, B.V., Jusuf, P.R. (2024) Establishment and comprehensive characterization of a novel dark-reared zebrafish model for myopia studies. Experimental Eye Research. 246:110009
- Drummond, B.E., Chambers, B.E., Wesselman, H.M., Gibson, S., Arceri, L., Ulrich, M.N., Gerlach, G.F., Kroeger, P.T., Leshchiner, I., Goessling, W., Wingert, R.A. (2022) osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2. Biomedicines. 10(11):
- Yang, S., Zhang, X., Li, X., Yin, X., Teng, L., Ji, G., Li, H. (2022) Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence. International Journal of Molecular Sciences. 23(14):
- Clark, B.S., Miesfeld, J.B., Flinn, M.A., Collery, R.F., Link, B.A. (2021) Dynamic Polarization of Rab11a Modulates Crb2a Localization and Impacts Signaling to Regulate Retinal Neurogenesis. Frontiers in cell and developmental biology. 8:608112
- Peng, X., Lai, K.S., She, P., Kang, J., Wang, T., Li, G., Zhou, Y., Sun, J., Jin, D., Xu, X., Liao, L., Liu, J., Lee, E., Poss, K.D., Zhong, T.P. (2020) Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Journal of molecular cell biology. 13(1):41-58
- Brock, C.K., Wallin, S.T., Ruiz, O.E., Samms, K.M., Mandal, A., Sumner, E.A., Eisenhoffer, G.T. (2019) Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance. Nature communications. 10:1044
- Hou, J., Liu, H., Wang, L., Duan, L., Li, S., Wang, X. (2018) Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio. Environmental science & technology. 52(14):7996-8004
- Frank, D.F., Miller, G.W., Connon, R.E., Geist, J., Lein, P.J. (2017) Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. PeerJ. 5:e4106
- Heid, J., Cencioni, C., Ripa, R., Baumgart, M., Atlante, S., Milano, G., Scopece, A., Kuenne, C., Guenther, S., Azzimato, V., Farsetti, A., Rossi, G., Braun, T., Pompilio, G., Martelli, F., Zeiher, A.M., Cellerino, A., Gaetano, C., Spallotta, F. (2017) Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health. Scientific Reports. 7:16839
1 - 10 of 33
Show