Gene
tfpia
- ID
- ZDB-GENE-030711-1
- Name
- tissue factor pathway inhibitor a
- Symbol
- tfpia Nomenclature History
- Previous Names
-
- tfpib
- si:dz44f8.1
- wu:fb92g01
- zgc:152844
- zgc:158592
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in blood coagulation. Predicted to act upstream of or within hemostasis and negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in caudal fin skeleton. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016594Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| unt3 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tfpia | Raman et al., 2021 | |
| MO1-tfpia | N/A | Raman et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020901 | Proteinase inhibitor I2, Kunitz, conserved site |
| Domain | IPR002223 | Pancreatic trypsin inhibitor Kunitz domain |
| Family | IPR008296 | Tissue factor pathway inhibitor-like |
| Family | IPR050098 | Tissue factor pathway inhibitor/Kunitz-type serine protease inhibitor-like |
| Homologous_superfamily | IPR036880 | Pancreatic trypsin inhibitor Kunitz domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Pancreatic trypsin inhibitor Kunitz domain | Pancreatic trypsin inhibitor Kunitz domain superfamily | Proteinase inhibitor I2, Kunitz, conserved site | Tissue factor pathway inhibitor/Kunitz-type serine protease inhibitor-like | Tissue factor pathway inhibitor-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:E7EXD1 | InterPro | 278 | |||||
| UniProtKB:B0S6C1 | InterPro | 279 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-7O19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-249O24 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-44F8 | ZFIN Curated Data | |
| Encodes | EST | fb92g01 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152844 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158592 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191634 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001309803 (1) | 2289 nt | ||
| Genomic | GenBank:CT943665 (2) | 150931 nt | ||
| Polypeptide | UniProtKB:B0S6C1 (1) | 279 aa |
- Raman, R., Fallatah, W., Al Qaryoute, A., Dhinoja, S., Jagadeeswaran, P. (2021) Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Scientific Reports. 11:15238
- Raman, R., Fallatah, W., Al Qaryoute, A., Ryon, M., Jagadeeswaran, P. (2021) Knockdown and Knockout of Tissue Factor Pathway Inhibitor in Zebrafish. Thrombosis and haemostasis. 122(7):1104-1114
- Schmid, S., Fent, K. (2019) 17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish. Environmental pollution (Barking, Essex : 1987). 259:113808
- Choi, T.Y., Khaliq, M., Tsurusaki, S., Ninov, N., Stainier, D.Y.R., Tanaka, M., Shin, D. (2017) Bmp Signaling Governs Biliary-Driven Liver Regeneration in Zebrafish via Tbx2b and Id2a. Hepatology (Baltimore, Md.). 66(5):1616-1630
- Joris, M., Schloesser, M., Baurain, D., Hanikenne, M., Muller, M., Motte, P. (2017) Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Nucleic acids research. 45:9547-9557
- Wang, L., Wang, X., Wang, L., Yousaf, M., Li, J., Zuo, M., Yang, Z., Gou, D., Bao, B., Li, L., Xiang, N., Jia, H., Xu, C., Chen, Q., Wang, Q.K. (2017) Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(1):183-194
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kessels, M.Y., Huitema, L.F., Boeren, S., Kranenbarg, S., Schulte-Merker, S., van Leeuwen, J.L., de Vries, S.C. (2014) Proteomics analysis of the zebrafish skeletal extracellular matrix. PLoS One. 9:e90568
- Martins, R., Vieira, F.A., Power, D.M. (2014) Calcitonin receptor family evolution and fishing for function using in silico promoter analysis. General and comparative endocrinology. 209:61-73
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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