ZFIN is now using GRCz12tu for Genomic Data
Gene
ctsc
- ID
- ZDB-GENE-030619-9
- Name
- cathepsin C
- Symbol
- ctsc Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in macrophage; neural crest; polster; somite; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb146 (4 images)
- cb912 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| aggressive periodontitis | Alliance | Periodontitis 1, aggressive | 170650 |
| Papillon-Lefevre disease | Alliance | Papillon-Lefevre syndrome | 245000 |
| Haim-Munk syndrome | 245010 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR014882 | Cathepsin C exclusion |
| Domain | IPR039412 | Cathepsin C |
| Family | IPR013128 | Peptidase C1A |
| Homologous_superfamily | IPR036496 | Cathepsin C, exclusion domain superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cathepsin C | Cathepsin C exclusion | Cathepsin C, exclusion domain superfamily | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P2V1 | InterPro | 455 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers