Gene
mrtfbb
- ID
- ZDB-GENE-030619-16
- Name
- myocardin related transcription factor Bb
- Symbol
- mrtfbb Nomenclature History
- Previous Names
-
- mkl2b
- si:ch73-83l13.1
- wu:fl04e06 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and smooth muscle cell differentiation. Predicted to be active in nucleus. Orthologous to human MRTFB (myocardin related transcription factor B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9339 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10111 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10413 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10883 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15353 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17904 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18765 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18766 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20120 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44573 | Allele with one point mutation | Unknown | Unknown | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Myocardin-like | RPEL repeat | SAP domain | SAP domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:X1WEC8 | InterPro | 903 | ||||
| UniProtKB:E7F442 | InterPro | 926 | ||||
| UniProtKB:A0AB32TL33 | InterPro | 962 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mrtfbb-201
(1)
|
Ensembl | 3,346 nt | ||
| mRNA |
mrtfbb-202
(1)
|
Ensembl | 5,295 nt | ||
| mRNA |
mrtfbb-203
(1)
|
Ensembl | 3,280 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-83L13 | ZFIN Curated Data | |
| Encodes | EST | fl04e06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009299740 (1) | 7837 nt | ||
| Genomic | GenBank:CR855302 (1) | 182196 nt | ||
| Polypeptide | UniProtKB:A0AB32TL33 (1) | 962 aa |
- Abu Nahia, K., Migdał, M., Quinn, T.A., Poon, K.L., Łapiński, M., Sulej, A., Liu, J., Mondal, S.S., Pawlak, M., Bugajski, Ł., Piwocka, K., Brand, T., Kohl, P., Korzh, V., Winata, C. (2021) Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region. Cellular and molecular life sciences : CMLS. 78(19-20):6669-6687
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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