Gene

plaub

ID
ZDB-GENE-030619-15
Name
plasminogen activator, urokinase b
Symbol
plaub Nomenclature History
Previous Names
  • wu:fk07g01
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase activity. Involved in plasminogen activation. Predicted to localize to extracellular space. Is expressed in several structures, including eye; gill; gonad; heart; and liver. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With plaub Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alzheimer's disease 1 Alliance {Alzheimer disease, late-onset, susceptibility to} 104300
Quebec platelet disorder Alliance Quebec platelet disorder 601709
Associated With plaub Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018114 Serine proteases, trypsin family, histidine active site
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Domain IPR000001 Kringle
Domain IPR000742 EGF-like domain
Domain IPR001254 Serine proteases, trypsin domain
Family IPR001314 Peptidase S1A, chymotrypsin family
Family IPR034814 Urokinase-type plasminogen activator
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR038178 Kringle superfamily
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
Domain Details Per Protein
Protein Length EGF-like domain Kringle Kringle-like fold Kringle superfamily Peptidase S1A, chymotrypsin family Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Serine proteases, trypsin domain Serine proteases, trypsin family, histidine active site Serine proteases, trypsin family, serine active site Urokinase-type plasminogen activator
UniProtKB:Q1RLR1 430
UniProtKB:G8CXX6 432
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations