Gene
plaub
- ID
- ZDB-GENE-030619-15
- Name
- plasminogen activator, urokinase b
- Symbol
- plaub Nomenclature History
- Previous Names
-
- wu:fk07g01
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have serine-type endopeptidase activity. Involved in plasminogen activation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal failure; lung disease (multiple); and mitral valve prolapse. Is expressed in several structures, including eye; gill; gonad; heart; and liver. Orthologous to human PLAU (plasminogen activator, urokinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Park et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Alzheimer's disease 1 | Alliance | {Alzheimer disease, late-onset, susceptibility to} | 104300 |
| Quebec platelet disorder | Alliance | Quebec platelet disorder | 601709 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Domain | IPR000001 | Kringle |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR050127 | Serine Proteases (Peptidase S1 Family) |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
Domain Details Per Protein
| Protein | Length | EGF-like domain | Kringle | Kringle-like fold | Kringle superfamily | Peptidase S1A, chymotrypsin family | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine Proteases (Peptidase S1 Family) | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q858
|
430 | |||||||||||
|
UniProtKB:G8CXX6
|
432 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance