Gene
inppl1b
- ID
- ZDB-GENE-030616-75
- Name
- inositol polyphosphate phosphatase-like 1b
- Symbol
- inppl1b Nomenclature History
- Previous Names
-
- inppl1
- ship2b (1)
- si:bz46j2.7
- si:rp71-46j2.7
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable inositol-polyphosphate 5-phosphatase activity. Predicted to be involved in negative regulation of insulin-like growth factor receptor signaling pathway and regulation of immune response. Predicted to act upstream of or within cell adhesion; immune system process; and phosphatidylinositol dephosphorylation. Predicted to be located in nuclear speck. Predicted to be active in cytosol.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Lam et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000300 | Inositol polyphosphate-related phosphatase |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036691 | Endonuclease/exonuclease/phosphatase superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Endonuclease/exonuclease/phosphatase superfamily | Inositol polyphosphate-related phosphatase | SH2 domain | SH2 domain superfamily | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1N8H7 | InterPro | 1226 | ||||||
| UniProtKB:Q2I6J0 | InterPro | 1226 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
inppl1b-201
(1)
|
Ensembl | 3,791 nt | ||
| mRNA |
inppl1b-202
(1)
|
Ensembl | 4,058 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-285J6 | ZFIN Curated Data | |
| Contained in | BAC | RP71-46J2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039135 (1) | 3771 nt | ||
| Genomic | GenBank:BX088596 | 142350 nt | ||
| Polypeptide | UniProtKB:A0A8M1N8H7 (1) | 1226 aa |
No data available
- Hawkey-Noble, A., Umali, J., Fowler, G., French, C.R. (2020) Expression of three P4- phospholipid Flippases-atp11a, atp11b, and atp11c in zebrafish (Danio rerio). Gene expression patterns : GEP. 36:119115
- Inaba, Y., Chauhan, V., van Loon, A.P., Choudhury, L.S., Sagasti, A. (2020) Keratins and Plakin family cytolinker proteins control the length of epithelial microridge protrusions. eLIFE. 9:
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lam, P.Y., Yoo, S.K., Green, J.M., and Huttenlocher, A. (2012) The SH2-domain-containing inositol 5-phosphatase (SHIP) limits neutrophil motility and wound recruitment in zebrafish. Journal of Cell Science. 125(21):4973-4978
- Jurynec, M.J., and Grunwald, D.J. (2010) SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo. Disease models & mechanisms. 3(11-12):733-742
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