Gene
acin1a
- ID
- ZDB-GENE-030616-583
- Name
- apoptotic chromatin condensation inducer 1a
- Symbol
- acin1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable nucleic acid binding activity. Predicted to be involved in RNA splicing. Predicted to be part of ASAP complex. Orthologous to human ACIN1 (apoptotic chromatin condensation inducer 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150749 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12080 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16806 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18032 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19828 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa25870 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32980 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32981 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39892 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39893 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa44541 | Allele with one point mutation | Unknown | Unknown | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR032552 | Acin1, RNSP1-SAP18 binding (RSB) motif |
| Domain | IPR003034 | SAP domain |
| Domain | IPR034257 | Acinus, RNA recognition motif |
| Family | IPR052793 | Exon junction complex-associated protein |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Acin1, RNSP1-SAP18 binding (RSB) motif | Acinus, RNA recognition motif | Exon junction complex-associated protein | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | SAP domain | SAP domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BIP8 | InterPro | 1928 | |||||||
| UniProtKB:A0A8M2BIJ9 | InterPro | 1929 | |||||||
| UniProtKB:A0A8M9Q0P4 | InterPro | 1951 | |||||||
| UniProtKB:A0A8M2BJ22 | InterPro | 1427 | |||||||
| UniProtKB:A0A8M3AQD0 | InterPro | 1426 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acin1a-202
(1)
|
Ensembl | 3,315 nt | ||
| mRNA |
acin1a-204
(1)
|
Ensembl | 2,378 nt | ||
| mRNA |
acin1a-205
(1)
|
Ensembl | 806 nt | ||
| mRNA |
acin1a-206
(1)
|
Ensembl | 779 nt | ||
| mRNA |
acin1a-207
(1)
|
Ensembl | 2,523 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-10E2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-14A17 | ZFIN Curated Data | |
| Encodes | EST | fb04g06 | ||
| Encodes | EST | fb40f03 | ||
| Encodes | EST | fb80f07 | ||
| Encodes | EST | fc12e10 | ||
| Encodes | EST | IMAGE:7150749 | Thisse et al., 2004 | |
| Encodes | EST | tdsubc_2g5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136424 | ZFIN Curated Data | |
| Has Artifact | EST | fb68h03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007105 (1) | 2389 nt | ||
| Genomic | GenBank:AL928674 (1) | 205118 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q0P4 (1) | 1951 aa |
- Lee, H.C., Hsieh, C.C., Tsai, H.J. (2022) KEPI Plays a Negative Role in the Repression that Accompanies Translational Inhibition Guided by the uORF Element of Human chop Transcript during Stress Response. Gene. 817:146160
- Matern, M.S., Beirl, A., Ogawa, Y., Song, Y., Paladugu, N., Kindt, K.S., Hertzano, R. (2018) Transcriptomic Profiling of Zebrafish Hair Cells Using RiboTag. Frontiers in cell and developmental biology. 6:47
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Quiniou, S.M., Wilson, M., and Boudinot, P. (2011) Processing of fish Ig heavy chain transcripts: Diverse splicing patterns and unusual nonsense mediated decay. Developmental and comparative immunology. 35(9):949-58
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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