Gene

scrib

ID

ZDB-GENE-030616-572

Name

scribble planar cell polarity protein

Symbol

scrib Nomenclature History

Previous Names

scrb1 (1)
landlocked
llk
scribble1 (1)
si:ch211-12p8.1 (1)
si:zc12p8.1

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Exhibits protein heterodimerization activity. Involved in several processes, including establishment of mitotic spindle orientation; morphogenesis of an epithelium; and nervous system development. Localizes to membrane. Predicted to colocalize with cell leading edge; ionotropic glutamate receptor complex; and synaptic membrane. Is expressed in brain and neural tube. Orthologous to human SCRIB (scribble planar cell polarity protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1089 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 20 figures from 11 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With scrib Human Ortholog

No data available

Associated With scrib Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001478	PDZ domain
Family	IPR050614	Synaptic Scaffolding LAP/MAGUK Families
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype

Domain Details Per Protein

Protein	Length	Leucine-rich repeat	Leucine-rich repeat domain superfamily	Leucine-rich repeat, typical subtype	PDZ domain	PDZ superfamily	Synaptic Scaffolding LAP/MAGUK Families
UniProtKB:A0A8M9Q190 InterPro	2010
UniProtKB:A0A8M9PNM8 InterPro	2011
UniProtKB:A0A8M9Q197 InterPro	1961
UniProtKB:A0A8M9QGP6 InterPro	1998
UniProtKB:A0A8M9QBQ7 InterPro	1900
UniProtKB:A0A8M9Q7L2 InterPro	1999
UniProtKB:A0A8M9Q7J8 InterPro	2047
UniProtKB:A0A8M9QGN8 InterPro	2046
UniProtKB:A0A8M9Q7L7 InterPro	1919
UniProtKB:A0A8M9QBP1 InterPro	2031
UniProtKB:A0A8M9PNM3 InterPro	2028
UniProtKB:A0A8M9Q1A3 InterPro	1998
UniProtKB:A0A8M9PNN3 InterPro	1974
UniProtKB:A0A8M9PNN8 InterPro	1887
UniProtKB:Q4H4B6 InterPro	1724
UniProtKB:A0A8M9Q7K5 InterPro	2022
UniProtKB:A0A8M9QBP6 InterPro	2015
UniProtKB:A0A8M9QBQ1 InterPro	1986
UniProtKB:A0A8M9QGP9 InterPro	1903
UniProtKB:A0A8M9Q183 InterPro	2026

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	scrib-201 (1) Ensembl	Ensembl	5,175 nt	Select Tool
mRNA	scrib-202 (1) Ensembl	Ensembl	5,600 nt	Select Tool
mRNA	scrib-205 (1) Ensembl	Ensembl	674 nt	Select Tool
mRNA	scrib-209 (1) Ensembl	Ensembl	7,921 nt	Select Tool
mRNA	scrib-210 (1) Ensembl	Ensembl	8,074 nt	Select Tool
ncRNA	scrib-002 (1) Ensembl	Ensembl	756 nt	Select Tool
ncRNA	scrib-003 (1) Ensembl	Ensembl	736 nt	Select Tool
ncRNA	scrib-004 (1) Ensembl	Ensembl	532 nt	Select Tool
ncRNA	scrib-005 (1) Ensembl	Ensembl	213 nt	Select Tool
ncRNA	scrib-006 (1) Ensembl	Ensembl	104 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations