ZFIN is now using GRCz12tu for Genomic Data

Gene

scrib

ID

ZDB-GENE-030616-572

Name

scribble planar cell polarity protein

Symbol

scrib Nomenclature History

Previous Names

scrb1 (1)
landlocked
llk
scribble1 (1)
si:ch211-12p8.1 (1)
si:zc12p8.1

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables protein heterodimerization activity. Acts upstream of or within several processes, including establishment of mitotic spindle orientation; morphogenesis of an epithelium; and nervous system development. Located in membrane. Is expressed in anterior-posterior polarized posterior lateral line neuromast; brain; neural tube; and secondary posterior lateral line primordium. Orthologous to human SCRIB (scribble planar cell polarity protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1089 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 20 figures from 11 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With scrib Human Ortholog

No data available

Associated With scrib Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001478	PDZ domain
Domain	IPR055414	Disease resistance R13L4/SHOC-2-like, LRR domain
Family	IPR050614	Synaptic Scaffolding LAP/MAGUK Families
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9Q190	InterPro	2010
UniProtKB:A0A8M9PNM8	InterPro	2011
UniProtKB:A0A8M9Q197	InterPro	1961
UniProtKB:A0A8M9QGP6	InterPro	1998
UniProtKB:A0A8M9QBQ7	InterPro	1900
UniProtKB:A0A8M9Q7L2	InterPro	1999
UniProtKB:A0A8M9Q7J8	InterPro	2047
UniProtKB:A0A8M9QGN8	InterPro	2046
UniProtKB:A0A8M9Q7L7	InterPro	1919
UniProtKB:A0A8M9QBP1	InterPro	2031
UniProtKB:A0A8M9PNM3	InterPro	2028
UniProtKB:A0A8M9Q1A3	InterPro	1998
UniProtKB:A0A8M9PNN3	InterPro	1974
UniProtKB:A0A8M9PNN8	InterPro	1887
UniProtKB:Q4H4B6	InterPro	1724
UniProtKB:A0A8M9Q7K5	InterPro	2022
UniProtKB:A0A8M9QBP6	InterPro	2015
UniProtKB:A0A8M9QBQ1	InterPro	1986
UniProtKB:A0A8M9QGP9	InterPro	1903
UniProtKB:A0A8M9Q183	InterPro	2026
UniProtKB:A0AB32TR43	InterPro	1817
UniProtKB:A0AB32TR63	InterPro	1852
UniProtKB:A0AB32TS16	InterPro	1994
UniProtKB:A0AB32TS35	InterPro	1714
UniProtKB:A0AB32TSD5	InterPro	1725
UniProtKB:A0AB32TTN5	InterPro	1938
UniProtKB:A0AB32TUG8	InterPro	1798
UniProtKB:A0AB32TUM1	InterPro	1937
UniProtKB:A0AB32TWD7	InterPro	1925
UniProtKB:A0AB32TWE1	InterPro	1744
UniProtKB:A0AB32TWY8	InterPro	1884
UniProtKB:A0AB32TXZ8	InterPro	1866
UniProtKB:A0AB32TY20	InterPro	1950
UniProtKB:A0AB32TY61	InterPro	1913
UniProtKB:A0AB32TZA1	InterPro	1888
UniProtKB:A0AC58FY65	InterPro	1786
UniProtKB:A0AC58FY76	InterPro	1818
UniProtKB:A0AC58FY81	InterPro	1750
UniProtKB:A0AC58FY96	InterPro	1781
UniProtKB:A0AC58FY97	InterPro	1834
UniProtKB:A0AC58FY99	InterPro	1692
UniProtKB:A0AC58FYA0	InterPro	1732
UniProtKB:A0AC58FYC1	InterPro	1769
UniProtKB:A0AC58FYC3	InterPro	1750
UniProtKB:A0AC58FYD4	InterPro	1733
UniProtKB:A0AC58FYD9	InterPro	1689
UniProtKB:A0AC58FYE1	InterPro	1777
UniProtKB:A0AC58FYE8	InterPro	1747
UniProtKB:A0AC58FYG4	InterPro	1686
UniProtKB:A0AC58FXP1	InterPro	1854
UniProtKB:A0AC58FXP3	InterPro	1853
UniProtKB:A0AC58FXQ3	InterPro	1835
UniProtKB:A0AC58FXQ4	InterPro	1806
UniProtKB:A0AC58FXQ7	InterPro	1799
UniProtKB:A0AC58FXQ8	InterPro	1777
UniProtKB:A0AC58FXQ9	InterPro	1776
UniProtKB:A0AC58FXR4	InterPro	1781
UniProtKB:A0AC58FXR5	InterPro	1770
UniProtKB:A0AC58FXR6	InterPro	1796
UniProtKB:A0AC58FXR7	InterPro	1761
UniProtKB:A0AC58FXR8	InterPro	1765
UniProtKB:A0AC58FXS0	InterPro	1792
UniProtKB:A0AC58FXS3	InterPro	1743
UniProtKB:A0AC58FXS4	InterPro	1740
UniProtKB:A0AC58FXS7	InterPro	1817
UniProtKB:A0AC58FXS8	InterPro	1713
UniProtKB:A0AC58FXS9	InterPro	1760
UniProtKB:A0AC58FXT0	InterPro	1749
UniProtKB:A0AC58FXT2	InterPro	1722
UniProtKB:A0AC58FXT3	InterPro	1797
UniProtKB:A0AC58FXT4	InterPro	1740
UniProtKB:A0AC58FXT5	InterPro	1751
UniProtKB:A0AC58FXU1	InterPro	1667
UniProtKB:A0AC58FXU4	InterPro	1707
UniProtKB:A0AC58FXU6	InterPro	1688
UniProtKB:A0AC58FXU8	InterPro	1768
UniProtKB:A0AC58FXU9	InterPro	1761
UniProtKB:A0AC58FXV3	InterPro	1703
UniProtKB:A0AC58FXW3	InterPro	1711
UniProtKB:A0AC58FXW4	InterPro	1728

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	scrib-201 (1) Ensembl	Ensembl	5,175 nt	Select Tool ZFIN BLAST
mRNA	scrib-202 (1) Ensembl	Ensembl	5,600 nt	Select Tool ZFIN BLAST
mRNA	scrib-205 (1) Ensembl	Ensembl	674 nt	Select Tool ZFIN BLAST
mRNA	scrib-209 (1) Ensembl	Ensembl	7,921 nt	Select Tool ZFIN BLAST
mRNA	scrib-210 (1) Ensembl	Ensembl	8,074 nt	Select Tool ZFIN BLAST
ncRNA	scrib-002 (1) Ensembl	Ensembl	756 nt	Select Tool ZFIN BLAST
ncRNA	scrib-003 (1) Ensembl	Ensembl	736 nt	Select Tool ZFIN BLAST
ncRNA	scrib-004 (1) Ensembl	Ensembl	532 nt	Select Tool ZFIN BLAST
ncRNA	scrib-005 (1) Ensembl	Ensembl	213 nt	Select Tool ZFIN BLAST
ncRNA	scrib-006 (1) Ensembl	Ensembl	104 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations