ZFIN ID: ZDB-GENE-030616-563
Gene Name: TATA box binding protein
Gene Symbol: tbp    Nomenclature History

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Previous Names: fd20h06, si:zc101n13.2, wu:fd20h06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits DNA binding activity. Involved in gastrulation; mRNA catabolic process; and transcription by RNA polymerase II. Predicted to localize to transcription factor TFIID complex and transcription factor TFIIIB complex. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human TBP (TATA-box binding protein).
Genome Resources: Alliance (1),  Gene:368882 (1),  Ensembl(GRCz11):ENSDARG00000014994 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66213]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018474Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018475Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tbp N/A 4
    MO2-tbp N/A 2
    MO3-tbp N/A 1
    DISEASE ASSOCIATED WITH tbp HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    late onset Parkinson's disease Alliance {Parkinson disease, susceptibility to} 168600
    spinocerebellar ataxia type 17 Alliance Spinocerebellar ataxia 17 607136
    DISEASE ASSOCIATED WITH tbp VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process gastrulation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbp-201 (1)    Ensembl 1774
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbp
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(tbp:EGFP) tbp EGFP Danio rerio 1 3
    Tg(tbp:GAL4) tbp GAL4 Danio rerio 0 8
    Tg(tbp:GAL4,myl7:Cerulean) myl7tbp CeruleanGAL4 Danio rerio 1 11
    MARKER RELATIONSHIPS
    tbp Contained in: [BAC] CH211-101N13 (1), CH211-202M22 (1)
    tbp Encodes: [EST] fd20h06
    [cDNA] MGC:66213 (1), MGC:77761 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200096 (1) 1745 nt
    Genomic GenBank:AL772154 (1) 173048 nt
    Select Tool
    Polypeptide UniProtKB:Q7SXL3 (1) 302 aa
    Sequence Information (all 20)
    ORTHOLOGY for tbp ( Chr: 13 )
    CITATIONS (84)