ZFIN is now using GRCz12tu for Genomic Data
Gene
tbp
- ID
- ZDB-GENE-030616-563
- Name
- TATA box binding protein
- Symbol
- tbp Nomenclature History
- Previous Names
-
- fd20h06
- si:zc101n13.2
- wu:fd20h06
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables DNA binding activity. Involved in gastrulation and mRNA catabolic process. Acts upstream of or within transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66213 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| late onset Parkinson's disease | Alliance | {Parkinson disease, susceptibility to} | 168600 |
| spinocerebellar ataxia 17 | Alliance | Spinocerebellar ataxia 17 | 607136 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | TATA-box binding protein | TATA-box binding protein, conserved site | TATA-box binding protein, eukaryotic | TBP domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q7SXL3 | InterPro | 302 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers