Gene

tbp

ID
ZDB-GENE-030616-563
Name
TATA box binding protein
Symbol
tbp Nomenclature History
Previous Names
  • fd20h06
  • si:zc101n13.2
  • wu:fd20h06
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits DNA binding activity. Involved in gastrulation; mRNA catabolic process; and transcription by RNA polymerase II. Predicted to localize to nuclear chromatin and transcription factor TFIID complex. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbp Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
late onset Parkinson's disease Alliance {Parkinson disease, susceptibility to} 168600
spinocerebellar ataxia type 17 Alliance Spinocerebellar ataxia 17 607136
Associated With tbp Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030491 TATA-box binding protein, conserved site
Family IPR000814 TATA-box binding protein
Family IPR033710 TATA-box binding protein, eukaryotic
Homologous_superfamily IPR012295 TBP domain superfamily
Domain Details Per Protein
Protein Length TATA-box binding protein TATA-box binding protein, conserved site TATA-box binding protein, eukaryotic TBP domain superfamily
UniProtKB:Q7SXL3 302
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations