Gene

kpna3

ID

ZDB-GENE-030616-541

Name

karyopherin alpha 3 (importin alpha 4)

Symbol

kpna3 Nomenclature History

Previous Names

si:dz79f24.2

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Orthologous to human KPNA3 (karyopherin subunit alpha 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63818 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kpna3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary spastic paraplegia 88	Alliance	Spastic paraplegia 88, autosomal dominant	620106

Associated With kpna3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002652	Importin-alpha, importin-beta-binding domain
Family	IPR024931	Importin subunit alpha
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036975	Importin-alpha, importin-beta-binding domain superfamily
Repeat	IPR000225	Armadillo
Repeat	IPR032413	Atypical Arm repeat

Domain Details Per Protein

Protein	Length	Armadillo	Armadillo-like helical	Armadillo-type fold	Atypical Arm repeat	Importin-alpha, importin-beta-binding domain	Importin-alpha, importin-beta-binding domain superfamily	Importin subunit alpha
UniProtKB:Q8JFT7 InterPro	520

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	kpna3-201 (1) Ensembl	Ensembl		3,998 nt	Select Tool ZFIN BLAST
mRNA	ottdart00000001842 (1)	Havana		1,816 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations