Gene
tubgcp3
- ID
- ZDB-GENE-030616-538
- Name
- tubulin gamma complex component 3
- Symbol
- tubgcp3 Nomenclature History
- Previous Names
-
- si:dz75p05.1
- wu:fc09h08
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Involved in neural retina development. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be part of gamma-tubulin small complex. Predicted to be active in centrosome and equatorial microtubule organizing center. Is expressed in ciliary marginal zone; head; and optic cup. Orthologous to human TUBGCP3 (tubulin gamma complex associated protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Li et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la013691Tg | Transgenic insertion | Unknown | Unknown | DNA | |
zf3126 | Allele with one deletion | Unknown | Unknown | CRISPR | |
zko902a | Allele with one deletion | Unknown | Unknown | CRISPR | |
zko902b | Allele with one insertion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR040457 | Gamma tubulin complex component, C-terminal |
Domain | IPR041470 | Gamma tubulin complex component protein, N-terminal |
Family | IPR007259 | Gamma-tubulin complex component protein |
Homologous_superfamily | IPR042241 | Gamma-tubulin complex component, C-terminal domain superfamily |
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Domain Details Per Protein
Protein | Length | Gamma tubulin complex component, C-terminal | Gamma-tubulin complex component, C-terminal domain superfamily | Gamma-tubulin complex component protein | Gamma tubulin complex component protein, N-terminal |
---|---|---|---|---|---|
UniProtKB:F1QA15
|
906 | ||||
UniProtKB:B8A509
|
899 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
tubgcp3-201
(1)
|
Ensembl | 6,710 nt | ||
mRNA |
tubgcp3-202
(1)
|
Ensembl | 3,947 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-113J6 | ZFIN Curated Data | |
Contained in | BAC | DKEY-263L8 | ZFIN Curated Data | |
Contained in | PAC | BUSM1-75P05 | ZFIN Curated Data | |
Encodes | EST | fc09h08 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001004513 (1) | 2700 nt | ||
Genomic | GenBank:BX465849 (1) | 136195 nt | ||
Polypeptide | UniProtKB:F1QA15 (1) | 906 aa |
- Hawkey-Noble, A., Umali, J., Fowler, G., French, C.R. (2020) Expression of three P4- phospholipid Flippases-atp11a, atp11b, and atp11c in zebrafish (Danio rerio). Gene expression patterns : GEP. 36:119115
- Li, G., Jin, D., Zhong, T.P. (2019) Tubgcp3 Is Required for Retinal Progenitor Cell Proliferation During Zebrafish Development. Frontiers in molecular neuroscience. 12:126
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Nakajima, H., Nakajima-Takagi, Y., Tsujita, T., Akiyama, S., Wakasa, T., Mukaigasa, K., Kaneko, H., Tamaru, Y., Yamamoto, M., and Kobayashi, M. (2011) Tissue-restricted expression of nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. PLoS One. 6(10):e26884
- Liu, J., and Lessman, C.A. (2007) Soluble tubulin complexes, gamma-tubulin, and their changing distribution in the zebrafish (Danio rerio) ovary, oocyte and embryo. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 147(1):56-73
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Okuda, Y., Yoda, H., Uchikawa, M., Furutani-Seiki, M., Takeda, H., Kondoh, H., Kamachi, Y. (2006) Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolution. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(3):811-825
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
- Martin, O.C., Gunawardane, R.N., Iwamatsu, A., and Zheng, Y. (1998) Xgrip109: a gamma tubulin-associated protein with an essential role in gamma tubulin ring complex (gammaTuRC) assembly and centrosome function. The Journal of cell biology. 141:675-687
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