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Gene

ptenb

ID
ZDB-GENE-030616-47
Name
phosphatase and tensin homolog B
Symbol
ptenb Nomenclature History
Previous Names
  • pten
  • fa11a08
  • fb73f10
  • fc83f12
  • fd16b10
  • fk90e11
  • si:bz1g13.4
  • wu:fa11a08
  • wu:fb73f10
  • wu:fc83f12
  • wu:fd16b10
  • wu:fk90e11
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Enables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in PML body and cytoplasm. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in several structures, including adaxial cell; blastomere; nervous system; neural rod; and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptenb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bannayan-Riley-Ruvalcaba syndrome Alliance Cowden syndrome 1 158350
Bannayan-Riley-Ruvalcaba syndrome Alliance Lhermitte-Duclos syndrome 158350
macrocephaly-autism syndrome Alliance Macrocephaly/autism syndrome 605309
prostate cancer Alliance Prostate cancer, somatic 176807
{Glioma susceptibility 2} 613028
{Meningioma} 607174
Associated With ptenb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Domain IPR014020 Tensin phosphatase, C2 domain
Domain IPR029023 Tensin-type phosphatase domain
Family IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Domain Details Per Protein
Protein Length Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like Tensin phosphatase, C2 domain Tensin-type phosphatase domain
UniProtKB:Q7ZZ56 399
UniProtKB:Q6TGR5 422
UniProtKB:Q561V0 289
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations