Gene
ptpn4a
- ID
- ZDB-GENE-030616-449
- Name
- protein tyrosine phosphatase non-receptor type 4a
- Symbol
- ptpn4a Nomenclature History
- Previous Names
-
- ptpn4
- fa16h07
- si:busm1-37o5.1
- si:dz37o5.1
- wu:fa16h07
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Orthologous to human PTPN4 (protein tyrosine phosphatase non-receptor type 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from van Eekelen et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Conserved_site | IPR019747 | FERM conserved site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR014847 | FERM adjacent |
| Domain | IPR018979 | FERM, N-terminal |
| Domain | IPR018980 | FERM, C-terminal PH-like domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR041783 | PTPN3/4, FERM domain C-lobe |
| Family | IPR012151 | Protein-tyrosine phosphatase, non-receptor type-3, -4 |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 4.1 domain | FERM/acyl-CoA-binding protein superfamily | FERM adjacent | FERM central domain | FERM conserved site | FERM, C-terminal PH-like domain | FERM domain | FERM, N-terminal | FERM superfamily, second domain | PDZ domain | PDZ superfamily | PH-like domain superfamily | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase, non-receptor type-3, -4 | PTPN3/4, FERM domain C-lobe | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JFS7 | InterPro | 921 | ||||||||||||||||||||
| UniProtKB:A0AB32U039 | InterPro | 929 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ottdart00000001903 (1) | Havana | 2,779 nt | ||
| mRNA |
ptpn4a-201
(1)
|
Ensembl | 6,112 nt | ||
| mRNA |
ptpn4a-202
(1)
|
Ensembl | 4,606 nt | ||
| mRNA |
ptpn4a-203
(1)
|
Ensembl | 393 nt | ||
| mRNA |
ptpn4a-204
(1)
|
Ensembl | 2,779 nt | ||
| mRNA |
ptpn4a-205
(1)
|
Ensembl | 2,842 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-116O1 | ZFIN Curated Data | |
| Contained in | BAC | CH211-81J7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-260F12 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-37O5 | ZFIN Curated Data | |
| Encodes | EST | fa16h07 | ||
| Encodes | cDNA | MGC:194143 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007200 (1) | 2779 nt | ||
| Genomic | GenBank:AL935307 (1) | 234744 nt | ||
| Polypeptide | UniProtKB:A0AB32U039 (1) | 929 aa |
- Horstick, E.J., Bayleyen, Y., Burgess, H.A. (2020) Molecular and cellular determinants of motor asymmetry in zebrafish. Nature communications. 11:1170
- Yu, T., Matsuda, M. (2020) Epb41l5 interacts with IQCB1 and regulates ciliary function in zebrafish embryos. Journal of Cell Science. 133(12):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wu, W., Hale, A.J., Lemeer, S., den Hertog, J. (2017) Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Scientific Reports. 7:8460
- Matsuda, M., Rand, K., Palardy, G., Shimizu, N., Ikeda, H., Nogare, D.D., Itoh, M., Chitnis, A.B. (2016) Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons. Development (Cambridge, England). 143(17):3085-96
- Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53
- van Eekelen, M., Overvoorde, J., van Rooijen, C., and den Hertog, J. (2010) Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. PLoS One. 5(9):e12573
- Hsu, Y.C., Willoughby, J.J., Christensen, A.K., and Jensen, A.M. (2006) Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size. Development (Cambridge, England). 133(24):4849-4859
- Jensen, A.M., and Westerfield, M. (2004) Zebrafish Mosaic Eyes Is a Novel FERM Protein Required for Retinal Lamination and Retinal Pigmented Epithelial Tight Junction Formation. Current biology : CB. 14(8):711-717
- Tsujikawa, M., and Malicki, J. (2004) Genetics of photoreceptor development and function in zebrafish. The International journal of developmental biology. 48(8-9):925-934
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