Gene
pde6a
- ID
- ZDB-GENE-030616-42
- Name
- phosphodiesterase 6A, cGMP-specific, rod, alpha
- Symbol
- pde6a Nomenclature History
- Previous Names
-
- si:bz1d10.3
- si:rp71-1d10.3
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling and retina development in camera-type eye. Predicted to act upstream of or within signal transduction. Predicted to be active in photoreceptor outer segment membrane. Is expressed in retina; retinal neural layer; retinal photoreceptor layer; and retinal rod cell. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 43. Orthologous to human PDE6A (phosphodiesterase 6A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Crouzier et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 43 | Alliance | Retinitis pigmentosa 43 | 613810 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| retinitis pigmentosa | pde6asa14581/sa14581 (AB) | standard conditions | Crouzier et al., 2021 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site |
| Domain | IPR002073 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Domain | IPR003018 | GAF domain |
| Domain | IPR003607 | HD/PDEase domain |
| Family | IPR023088 | 3'5'-cyclic nucleotide phosphodiesterase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | 3'5'-cyclic nucleotide phosphodiesterase | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | GAF domain | GAF-like domain superfamily | HD/PDEase domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q800E7 | InterPro | 858 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-1D10 | ZFIN Curated Data | |
| Contains | STS | chunp06815 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007160 (1) | 3062 nt | ||
| Genomic | GenBank:AL645792 (1) | 170221 nt | ||
| Polypeptide | UniProtKB:Q800E7 (1) | 858 aa |
- Liu, X., Han, S., Liu, F., Yu, S., Qin, Y., Li, J., Jia, D., Gao, P., Chen, X., Tang, Z., Liu, M., Huang, Y. (2023) Retinal degeneration in rpgra mutant zebrafish. Frontiers in cell and developmental biology. 11:11699411169941
- Ulhaq, Z.S., Okamoto, K., Ogino, Y., Fai Tse, W.K. (2023) Dysregulation of spliceosomes complex induces retinitis pigmentosa-like characteristics in sf3b4-depleted zebrafish. The American journal of pathology. 193(9):1223-1233
- Wei, X.Y., Jia, P.P., Hu, H., Liu, L., Li, T.Y., Li, Y.Z., Pei, D.S. (2023) Multi-omics reveal mechanisms underlying chronic kidney disease of unknown etiology (CKDu) pathogenesis using zebrafish. Environmental pollution (Barking, Essex : 1987). 337:122524
- Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., Zhao, G. (2022) Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International Journal of Molecular Sciences. 23(9)
- Crouzier, L., Diez, C., Richard, E.M., Cubedo, N., Barbereau, C., Rossel, M., Delaunay, T., Maurice, T., Delprat, B. (2021) Loss of Pde6a Induces Rod Outer Segment Shrinkage and Visual Alterations in pde6aQ70X Mutant Zebrafish, a Relevant Model of Retinal Dystrophy. Frontiers in cell and developmental biology. 9:675517
- Li, X., Xiong, D., Ju, Z., Xiong, Y., Ding, G., Liao, G. (2020) Phenotypic and transcriptomic consequences in zebrafish early-life stages following exposure to crude oil and chemical dispersant at sublethal concentrations. The Science of the total environment. 763:143053
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Abalo, X.M., Lagman, D., Heras, G., Del Pozo, A., Eggert, J., Larhammar, D. (2019) Circadian regulation of phosphodiesterase 6 genes in zebrafish differs between cones and rods: Implications for photopic and scotopic vision. Vision Research. 166:43-51
- Bridges, K.N., Magnuson, J.T., Curran, T.E., Barker, A., Roberts, A.P., Venables, B.J. (2019) Alterations to the vision-associated transcriptome of zebrafish (Danio rerio) following developmental norethindrone exposure. Environmental Toxicology and Pharmacology. 69:137-142
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
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