Gene

pde6a

ID
ZDB-GENE-030616-42
Name
phosphodiesterase 6A, cGMP-specific, rod, alpha
Symbol
pde6a Nomenclature History
Previous Names
  • si:bz1d10.3
  • si:rp71-1d10.3
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have 3',5'-cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in retina development in camera-type eye and signal transduction. Predicted to localize to photoreceptor outer segment membrane. Is expressed in retina; retinal neural layer; and retinal photoreceptor layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa 43. Orthologous to human PDE6A (phosphodiesterase 6A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pde6a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
retinitis pigmentosa 43 Alliance Retinitis pigmentosa 43 613810
Associated With pde6a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain IPR003018 GAF domain
Domain IPR003607 HD/PDEase domain
Family IPR023088 3'5'-cyclic nucleotide phosphodiesterase
Family IPR032958 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Homologous_superfamily IPR029016 GAF-like domain superfamily
Homologous_superfamily IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
Domain Details Per Protein
Protein Length 3'5'-cyclic nucleotide phosphodiesterase 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily 3'5'-cyclic nucleotide phosphodiesterase, conserved site GAF domain GAF-like domain superfamily HD/PDEase domain Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
UniProtKB:Q800E7 858
UniProtKB:A0A2R8QNZ0 842
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations