Gene
strn3
- ID
- ZDB-GENE-030616-405
- Name
- striatin, calmodulin binding protein 3
- Symbol
- strn3 Nomenclature History
- Previous Names
-
- id:ibd1241
- si:busm1-115o7.2
- si:dz115o7.2
- si:dz234g15.7
- wu:fc02f06
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable calmodulin binding activity and protein phosphatase 2A binding activity. Predicted to be involved in negative regulation of intracellular estrogen receptor signaling pathway. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in dendrite. Is expressed in intertectal commissure; optic tectum; somite; and tail bud. Orthologous to human STRN3 (striatin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Berger et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027840Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| pc45 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa16391 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa23096 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23097 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32155 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-strn3 | Berger et al., 2022 | |
| CRISPR2-strn3 | Berger et al., 2022 | |
| MO1-strn3 | N/A | Ahmed et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR013258 | Striatin, N-terminal |
| Family | IPR051488 | WD repeat-containing striatin |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Length | G-protein beta WD-40 repeat | Striatin, N-terminal | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WD repeat-containing striatin |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A9JRZ4
|
700 | |||||||
|
UniProtKB:A0A8M2B571
|
718 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-18B8 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-115O7 | ||
| Contained in | PAC | BUSM1-234G15 | ZFIN Curated Data | |
| Encodes | EST | fc02f06 | ||
| Encodes | EST | ibd1241 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175239 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013266 (1) | 3855 nt | ||
| Genomic | GenBank:CT027675 (1) | 191232 nt | ||
| Polypeptide | UniProtKB:A0A8M2B571 (1) | 718 aa |
- Ahmed, M., Kojima, Y., Masai, I. (2022) Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation. eLIFE. 11:
- Berger, J., Berger, S., Currie, P.D. (2022) Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth. PLoS Genetics. 18:e1010287
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- De Wit, M., Keil, D., Remmerie, N., Ven, K.V., Brandhof, E.J., Knapen, D., Witters, E., and Coen, W.D. (2008) Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches. Chemosphere. 74(1):96-105
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Coimbra, R.S., Weil, D., Brottier, P., Blanchard, S., Levi, M., Hardelin, J.-P., Weissenbach, J., and Petit, C. (2002) A subtracted cDNA library from the zebrafish (Danio rerio) embryonic inner ear. Genome research. 12(6):1007-1011
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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