Gene

adh8a

ID

ZDB-GENE-030529-3

Name

alcohol dehydrogenase 8a

Symbol

adh8a Nomenclature History

Previous Names

wu:fb62f02
zgc:77878

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Enables alcohol dehydrogenase (NAD+) activity. Acts upstream of or within cellular response to xenobiotic stimulus and ethanol metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; liver; and ovary. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adh8a Human Ortholog

No data available

Associated With adh8a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR002328	Alcohol dehydrogenase, zinc-type, conserved site
Domain	IPR013149	Alcohol dehydrogenase-like, C-terminal
Domain	IPR013154	Alcohol dehydrogenase-like, N-terminal
Domain	IPR020843	Polyketide synthase, enoylreductase domain
Homologous_superfamily	IPR011032	GroES-like superfamily
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily