Gene

adh8a

ID
ZDB-GENE-030529-3
Name
alcohol dehydrogenase 8a
Symbol
adh8a Nomenclature History
Previous Names
  • wu:fb62f02
  • zgc:77878
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Enables alcohol dehydrogenase (NAD+) activity. Acts upstream of or within cellular response to xenobiotic stimulus and ethanol metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; liver; and ovary. Human ortholog(s) of this gene implicated in alcohol dependence; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa11223Allele with one point mutationUnknownSplice SiteENU
sa14886Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With adh8a Human Ortholog
No data available
Associated With adh8a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
Domain IPR013149 Alcohol dehydrogenase-like, C-terminal
Domain IPR013154 Alcohol dehydrogenase-like, N-terminal
Domain IPR020843 Polyketide synthase, enoylreductase domain
Homologous_superfamily IPR011032 GroES-like superfamily
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Domain Details Per Protein
Protein Length Alcohol dehydrogenase-like, C-terminal Alcohol dehydrogenase-like, N-terminal Alcohol dehydrogenase, zinc-type, conserved site GroES-like superfamily NAD(P)-binding domain superfamily Polyketide synthase, enoylreductase domain
UniProtKB:Q6P0S5 377
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 13
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA adh8a-201 (1) Ensembl 1,433 nt
ncRNA adh8a-002 (1) Ensembl 578 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
No data available
Citations
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