Gene
adh8a
- ID
- ZDB-GENE-030529-3
- Name
- alcohol dehydrogenase 8a
- Symbol
- adh8a Nomenclature History
- Previous Names
-
- wu:fb62f02
- zgc:77878
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Exhibits alcohol dehydrogenase (NAD+) activity. Involved in cellular response to xenobiotic stimulus and ethanol metabolic process. Predicted to localize to cytosol. Is expressed in female organism; intestine; liver; and ovary. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR002328 | Alcohol dehydrogenase, zinc-type, conserved site |
Domain | IPR013149 | Alcohol dehydrogenase-like, C-terminal |
Domain | IPR013154 | Alcohol dehydrogenase-like, N-terminal |
Domain | IPR020843 | Polyketide synthase, enoylreductase domain |
Homologous_superfamily | IPR011032 | GroES-like superfamily |
Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
Protein | Length | Alcohol dehydrogenase-like, C-terminal | Alcohol dehydrogenase-like, N-terminal | Alcohol dehydrogenase, zinc-type, conserved site | GroES-like superfamily | NAD(P)-binding domain superfamily | Polyketide synthase, enoylreductase domain |
---|---|---|---|---|---|---|---|
UniProtKB:Q6P0S5
|
377 |
Interactions and Pathways
No data available
Plasmids
No data available