Gene
tnnc1a
- ID
- ZDB-GENE-030523-1
- Name
- troponin C type 1a (slow)
- Symbol
- tnnc1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity; calcium-dependent protein binding activity; and troponin I binding activity. Acts upstream of or within cardiac muscle contraction; cardiac ventricle development; and response to activity. Predicted to be part of cardiac Troponin complex. Is expressed in heart primordium; mesoderm; muscle; and pericardial region. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Z; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 13. Orthologous to human TNNC1 (troponin C1, slow skeletal and cardiac type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103465 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| az5 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| az6 | Allele with one delins | Unknown | Unknown | CRISPR | |
| m656 | unknown | Unknown | Unknown | ENU | |
| sa14726 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15521 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa25192 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sk25 | Allele with one deletion | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tnnc1a | Takada et al., 2017 | |
| MO1-tnnc1a | N/A | Sogah et al., 2010 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1Z | Alliance | Cardiomyopathy, dilated, 1Z | 611879 |
| hypertrophic cardiomyopathy 13 | Alliance | Cardiomyopathy, hypertrophic, 13 | 613243 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calmodulin/Myosin light chain/Troponin C-like | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair |
|---|---|---|---|---|---|---|
| UniProtKB:Q5XJB2 | InterPro | 161 | ||||
| UniProtKB:Q800V7 | InterPro | 161 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnnc1a-201
(1)
|
Ensembl | 1,089 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(TETRE:tnnc1a,EGFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-117K14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103465 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192052 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181498 (1) | 1066 nt | ||
| Genomic | GenBank:CR354596 (1) | 172749 nt | ||
| Polypeptide | UniProtKB:Q5XJB2 (1) | 161 aa |
- Bradshaw, M., Squire, J.M., Morris, E., Atkinson, G., Richardson, R., Lees, J., Caputo, M., Bigotti, G.M., Paul, D.M. (2023) Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio. Journal of muscle research and cell motility. 44(3):179-192
- Cai, W., Wang, Y., Luo, Y., Gao, L., Zhang, J., Jiang, Z., Fan, X., Li, F., Xie, Y., Wu, X., Li, Y., Yuan, W. (2023) asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. International Journal of Molecular Sciences. 24(22):
- Zhou, C., Zhao, W., Zhang, S., Ma, J., Sultan, Y., Li, X. (2022) High-throughput transcriptome sequencing reveals the key stages of cardiovascular development in zebrafish embryos. BMC Genomics. 23:587
- Ma, J., Huang, Y., Jiang, P., Liu, Z., Luo, Q., Zhong, K., Yuan, W., Meng, Y., Lu, H. (2021) Pyridaben induced cardiotoxicity during the looping stages of zebrafish (Danio rerio) embryos. Aquatic toxicology (Amsterdam, Netherlands). 237:105870
- Ma, J., Huang, Y., Peng, Y., Xu, Z., Wang, Z., Chen, X., Xie, S., Jiang, P., Zhong, K., Lu, H. (2021) Bifenazate exposure induces cardiotoxicity in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 274:116539
- Sundarrajan, L., Rajeswari, J.J., Weber, L.P., Unniappan, S. (2021) The sympathetic/beta-adrenergic pathway mediates irisin regulation of cardiac functions in zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 259:111016
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Huang, Y., Chen, Z., Meng, Y., Wei, Y., Xu, Z., Ma, J., Zhong, K., Cao, Z., Liao, X., Lu, H. (2020) Famoxadone-cymoxanil induced cardiotoxicity in zebrafish embryos. Ecotoxicology and environmental safety. 205:111339
- Li, S., Wu, Q., Sun, Q., Coffin, S., Gui, W., Zhu, G. (2019) Parental exposure to tebuconazole causes thyroid endocrine disruption in zebrafish and developmental toxicity in offspring. Aquatic toxicology (Amsterdam, Netherlands). 211:116-123
- Liu, L., Fei, F., Zhang, R., Wu, F., Yang, Q., Wang, F., Sun, S., Zhao, H., Li, Q., Wang, L., Wang, Y., Gui, Y., Wang, X. (2019) Combinatorial genetic replenishments in myocardial and outflow tract tissues restore heart function in tnnt2 mutant zebrafish. Biology Open. 8(12):
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