Gene

tnnc1a

ID
ZDB-GENE-030523-1
Name
troponin C type 1a (slow)
Symbol
tnnc1a Nomenclature History
Previous Names
  • cTnC (1)
  • ctnnc (1)
  • tnnc1
  • sil
  • zgc:103465
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity; calcium ion binding activity; and calcium-dependent protein binding activity. Involved in cardiac muscle contraction; cardiac ventricle development; and response to activity. Predicted to localize to troponin complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Z; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 13. Is expressed in heart primordium; mesoderm; muscle; and pericardial region. Orthologous to human TNNC1 (troponin C1, slow skeletal and cardiac type).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnnc1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dilated cardiomyopathy 1Z Alliance Cardiomyopathy, dilated, 1Z 611879
hypertrophic cardiomyopathy 13 Alliance Cardiomyopathy, hypertrophic, 13 613243
Associated With tnnc1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Domain IPR002048 EF-hand domain
Homologous_superfamily IPR011992 EF-hand domain pair
Domain Details Per Protein
Protein Length EF-Hand 1, calcium-binding site EF-hand domain EF-hand domain pair
UniProtKB:Q5XJB2 161
UniProtKB:Q800V7 161
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations