Gene

nrp1a

ID
ZDB-GENE-030519-2
Name
neuropilin 1a
Symbol
nrp1a Nomenclature History
Previous Names
  • np-1
  • npn-1A (1)
  • nrp1
  • znrp1
  • zgc:111785 (1)
  • zgc:136674 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Enables vascular endothelial growth factor receptor activity. Acts upstream of or within with a positive effect on angiogenesis involved in wound healing and cell activation. Acts upstream of or within several processes, including axon development; circulatory system development; and regulation of neuron projection development. Predicted to be located in membrane. Predicted to be active in axon and focal adhesion. Is expressed in several structures, including cardiovascular system; cranial neural crest cell; hematopoietic stem cell; hypochord; and nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NRP1 (neuropilin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
39 figures from 31 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 12 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nrp1a Human Ortholog
No data available
Associated With nrp1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000421 Coagulation factor 5/8 C-terminal domain
Domain IPR000859 CUB domain
Domain IPR000998 MAM domain
Domain IPR022579 Neuropilin, C-terminal
Family IPR014648 Neuropilin
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
Domain Details Per Protein
Protein Length Coagulation factor 5/8 C-terminal domain Concanavalin A-like lectin/glucanase domain superfamily CUB domain Galactose-binding-like domain superfamily MAM domain Neuropilin Neuropilin, C-terminal Spermadhesin, CUB domain superfamily
UniProtKB:A0A0R4IFP8 926
UniProtKB:Q8QFX6 923
UniProtKB:Q69DB8 923
UniProtKB:A0A8M3AYV8 919
UniProtKB:Q1RLY9 916
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations