ZFIN is now using GRCz12tu for Genomic Data
Gene
nrp1a
- ID
- ZDB-GENE-030519-2
- Name
- neuropilin 1a
- Symbol
- nrp1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables vascular endothelial growth factor receptor activity. Involved in several processes, including positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of filopodium assembly; and vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within with a positive effect on angiogenesis involved in wound healing and cell activation. Acts upstream of or within several processes, including axon development; circulatory system development; and regulation of neuron projection development. Predicted to be located in membrane. Predicted to be active in axon; focal adhesion; and plasma membrane. Is expressed in several structures, including cardiovascular system; cranial neural crest cell; hematopoietic stem cell; hypochord; and nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and tetralogy of Fallot. Orthologous to human NRP1 (neuropilin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000421 | Coagulation factor 5/8, C-terminal domain |
| Domain | IPR000859 | CUB domain |
| Domain | IPR000998 | MAM domain |
| Domain | IPR022579 | Neuropilin, C-terminal |
| Family | IPR014648 | Neuropilin |
| Family | IPR050633 | Neuropilin/Multicopper Oxidase/Coagulation Factor |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Coagulation factor 5/8, C-terminal domain | Concanavalin A-like lectin/glucanase domain superfamily | CUB domain | Galactose-binding-like domain superfamily | MAM domain | Neuropilin | Neuropilin, C-terminal | Neuropilin/Multicopper Oxidase/Coagulation Factor | Spermadhesin, CUB domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IFP8 | InterPro | 926 | |||||||||
| UniProtKB:Q8QFX6 | InterPro | 923 | |||||||||
| UniProtKB:Q69DB8 | InterPro | 923 | |||||||||
| UniProtKB:A0A8M3AYV8 | InterPro | 919 | |||||||||
| UniProtKB:Q1RLY9 | InterPro | 916 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers