Gene
nrarpb
- ID
- ZDB-GENE-030515-7
- Name
- NOTCH regulated ankyrin repeat protein b
- Symbol
- nrarpb Nomenclature History
- Previous Names
-
- zgc:101875
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Acts upstream of or within blood vessel endothelial cell proliferation involved in sprouting angiogenesis; branching involved in blood vessel morphogenesis; and regulation of cell-cell adhesion. Is expressed in several structures, including central nervous system; neural plate; neural rod; neural tube; and segmental plate. Orthologous to human NRARP (NOTCH regulated ankyrin repeat protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu603 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Phng et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025262Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20577 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Protein Phosphatase 1 Regulatory Subunit |
|---|---|---|---|---|---|
| UniProtKB:B2GQY1 | InterPro | 111 | |||
| UniProtKB:Q7T3X9 | InterPro | 111 | |||
| UniProtKB:A0AB32TV44 | InterPro | 133 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nrarpb-201
(1)
|
Ensembl | 3,296 nt | ||
| mRNA |
nrarpb-202
(1)
|
Ensembl | 518 nt | ||
| mRNA |
nrarpb-203
(1)
|
Ensembl | 339 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | eu603 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:101875 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192091 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181496 (1) | 3271 nt | ||
| Genomic | GenBank:FP340311 (1) | 110126 nt | ||
| Polypeptide | UniProtKB:A0AB32TV44 (1) | 133 aa |
- He, L., Zhang, Q., Jiang, D., Zhang, Y., Wei, Y., Yang, Y., Li, N., Wang, S., Yue, Y., Zhao, Q. (2021) Zebrafish foxc1a controls ventricular chamber maturation by directly regulating wwtr1 and nkx2.5 expression. Journal of genetics and genomics = Yi chuan xue bao. 49(6):559-568
- Li, G.X., Zhang, S., Liu, R., Singh, B., Singh, S., Quinn, D.I., Crump, G., Gill, P.S. (2020) Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biology Open. 10(2):
- Shi, W.J., Zhao, J.L., Jiang, Y.X., Huang, G.Y., Liu, Y.S., Zhang, J.N., Ying, G.G. (2017) TRANSCRIPTIONAL AND HISTOLOGICAL ALTERATIONS IN GONAD OF ADULT ZEBRAFISH AFTER EXPOSURE TO THE SYNTHETIC PROGESTIN NORGESTREL. Environmental toxicology and chemistry. 36(12):3267-3276
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Liu, L.Y., Lin, M.H., Lai, Z.Y., Jiang, J.P., Huang, Y.C., Jao, L.E., Chuang, Y.J. (2016) Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. Journal of Biomedical Science. 23:59
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Aday, A.W., Zhu, L.J., Lakshmanan, A., Wang, J., and Lawson, N.D. (2011) Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites. Developmental Biology. 357(2):450-62
- Krueger, J., Liu, D., Scholz, K., Zimmer, A., Shi, Y., Klein, C., Siekmann, A., Schulte-Merker, S., Cudmore, M., Ahmed, A., le Noble, F. (2011) Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Development (Cambridge, England). 138(10):2111-2120
- Phng, L.K., Potente, M., Leslie, J.D., Babbage, J., Nyqvist, D., Lobov, I., Ondr, J.K., Rao, S., Lang, R.A., Thurston, G., and Gerhardt, H. (2009) Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Developmental Cell. 16(1):70-82
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