Gene
prl
- ID
- ZDB-GENE-030513-1
- Name
- prolactin
- Symbol
- prl Nomenclature History
- Previous Names
-
- prl1 (1)
- zgc:110500
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity. Acts upstream of or within monoatomic ion homeostasis; multicellular organismal response to stress; and negative regulation of apoptotic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including adenohypophyseal placode; female organism; hypophysis; male organism; and peptide hormone secreting cell. Human ortholog(s) of this gene implicated in carotid artery disease and impulse control disorder. Orthologous to human PRL (prolactin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 61 figures from 34 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Somatotropin hormone, conserved site | Somatotropin/prolactin |
|---|---|---|---|---|---|
| UniProtKB:Q569P7 | InterPro | 210 |
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Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(prl:RFP) |
|
| 1 | (10) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-16P21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110500 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181437 (1) | 1425 nt | ||
| Genomic | GenBank:BX511021 (1) | 235632 nt | ||
| Polypeptide | UniProtKB:Q569P7 (1) | 210 aa |
- Roisman-Geller, N., Pisanty, O., Weinberger, A., Gajbhiye, D.S., Golan, M., Gothilf, Y. (2024) Combined Pituitary Hormone Deficiency in lhx4-Knockout Zebrafish. International Journal of Molecular Sciences. 25(13):
- Heidary, S., Awasthi, N., Page, N., Allnutt, T., Lewis, R.S., Liongue, C., Ward, A.C. (2023) A zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1). Cellular and molecular life sciences : CMLS. 80:109109
- Yan, C.Y., Wu, F.Y., Sun, F., Fang, Y., Zhang, R.J., Zhang, C.R., Zhang, C.X., Wang, Z., Yang, R.M., Yang, L., Dong, M., Zhang, Q.Y., Ye, X.P., Song, H.D., Zhao, S.X. (2023) The isl2a transcription factor regulates pituitary development in zebrafish. Frontiers in endocrinology. 14:920548920548
- Lee, J.S., Kawai, Y.K., Morita, Y., Covaci, A., Kubota, A. (2022) Estrogenic and growth inhibitory responses to organophosphorus flame retardant metabolites in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 256:109321
- Shi, S., Shu, T., Li, X., Lou, Q., Jin, X., He, J., Yin, Z., Zhai, G. (2022) Characterization of the Interrenal Gland and Sexual Traits Development in cyp17a2-Deficient Zebrafish. Frontiers in endocrinology. 13:910639
- Ren, Q., Gao, D., Mou, L., Zhang, S., Zhang, M., Li, N., Sik, A., Jin, M., Liu, K. (2021) Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. European Journal of Pharmacology. 912:174589
- Song, J., Lu, Y., Cheng, X., Shi, C., Lou, Q., Jin, X., He, J., Zhai, G., Yin, Z. (2021) Functions of the Thyroid-Stimulating Hormone on Key Developmental Features Revealed in a Series of Zebrafish Dyshormonogenesis Models. Cells. 10(8):
- Zhang, Y., Jiao, Y., Tao, Y., Li, Z., Yu, H., Han, S., Yang, Y. (2021) Monobutyl phthalate can induce autophagy and metabolic disorders by activating the ire1a-xbp1 pathway in zebrafish liver. Journal of hazardous materials. 412:125243
- Bando, H., Gergics, P., Bohnsack, B.L., Toolan, K.P., Richter, C.E., Shavit, J.A., Camper, S.A. (2020) otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease. Human molecular genetics. 29(10):1648-1657
- Fabian, P., Tseng, K.C., Smeeton, J., Lancman, J.J., Dong, P.D.S., Cerny, R., Crump, J.G. (2020) Lineage analysis reveals an endodermal contribution to the vertebrate pituitary. Science (New York, N.Y.). 370:463-467
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