Gene

bin1b

ID

ZDB-GENE-030425-1

Name

bridging integrator 1b

Symbol

bin1b Nomenclature History

Previous Names

bin1
cb57 (1)
im:7137547 (1)
si:ch211-114n24.7
zgc:86701

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable phospholipid binding activity and tau protein binding activity. Acts upstream of or within T-tubule organization and cardiac muscle contraction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane and synaptic vesicle. Is expressed in adaxial cell; cardiovascular system; musculature system; pectoral fin bud; and somite. Used to study centronuclear myopathy 2. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Orthologous to human BIN1 (bridging integrator 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb57 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bin1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
centronuclear myopathy 2	Alliance	Centronuclear myopathy 2	255200

Associated With bin1b Via Experimental Models

Human Disease	Fish	Conditions	Citations
centronuclear myopathy 2	AB + MO2-bin1b	control	Smith et al., 2014
centronuclear myopathy 2	AB + MO1-bin1b	control	Smith et al., 2014

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR004148	BAR domain
Domain	IPR035471	Amphiphysin 2, SH3 domain
Family	IPR003005	Amphiphysin
Homologous_superfamily	IPR027267	AH/BAR domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	AH/BAR domain superfamily	Amphiphysin	Amphiphysin 2, SH3 domain	BAR domain	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A8M3AT31 InterPro	543
UniProtKB:A0A8M3B348 InterPro	533
UniProtKB:A0A8M9QFB8 InterPro	407
UniProtKB:A0A8M9QAA8 InterPro	396
UniProtKB:A0A8M3AT25 InterPro	564
UniProtKB:A0A8M3B066 InterPro	451
UniProtKB:A0A8M3BA55 InterPro	545
UniProtKB:A0A2R8QMI5 InterPro	576
UniProtKB:F1QRX4 InterPro	364
UniProtKB:A0A8M3B064 InterPro	565
UniProtKB:A0A8M3AT30 InterPro	440
UniProtKB:A0A8M9PZM7 InterPro	568

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
lincRNA	si:ch211-114n24.7-001 (1) Ensembl	Ensembl	2,053 nt	Select Tool ZFIN BLAST
mRNA	bin1b-201 (1) Ensembl	Ensembl	1,878 nt	Select Tool ZFIN BLAST
mRNA	bin1b-202 (1) Ensembl	Ensembl	867 nt	Select Tool ZFIN BLAST
mRNA	bin1b-203 (1) Ensembl	Ensembl	756 nt	Select Tool ZFIN BLAST
mRNA	bin1b-204 (1) Ensembl	Ensembl	777 nt	Select Tool ZFIN BLAST
mRNA	bin1b-205 (1) Ensembl	Ensembl	2,520 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations