Gene
kdm5bb
- ID
- ZDB-GENE-030424-1
- Name
- lysine demethylase 5Bb
- Symbol
- kdm5bb Nomenclature History
- Previous Names
-
- cb264 (1)
- jarid1bb
- plu1
- wu:fc44h11
- zgc:85741
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable histone H3K4me/H3K4me2/H3K4me3 demethylase activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin organization. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including hindbrain neural plate; musculature system; nervous system; neural tube; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 65; breast cancer; and high grade glioma. Orthologous to human KDM5B (lysine demethylase 5B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb264 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 65 | Alliance | Intellectual developmental disorder, autosomal recessive 65 | 618109 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR001606 | ARID DNA-binding domain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR003347 | JmjC domain |
| Domain | IPR003349 | JmjN domain |
| Domain | IPR004198 | Zinc finger, C5HC2-type |
| Domain | IPR013637 | Lysine-specific demethylase-like domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR047978 | Lysine-specific demethylase 5B, first PHD-finger |
| Domain | IPR047979 | Lysine-specific demethylase 5B, third PHD-finger |
| Domain | IPR047981 | Lysine-specific demethylase 5B, ARID domain |
| Domain | IPR048615 | Lysine-specific demethylase 5, C-terminal helical domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036431 | ARID DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | ARID DNA-binding domain | ARID DNA-binding domain superfamily | JmjC domain | JmjN domain | Lysine-specific demethylase 5B, ARID domain | Lysine-specific demethylase 5B, first PHD-finger | Lysine-specific demethylase 5B, third PHD-finger | Lysine-specific demethylase 5, C-terminal helical domain | Lysine-specific demethylase-like domain | Zinc finger, C5HC2-type | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:G1K2I1 | InterPro | 1522 | |||||||||||||||
| UniProtKB:Q6IQX0 | InterPro | 1503 | |||||||||||||||
| UniProtKB:A0A8M3BBT1 | InterPro | 1521 | |||||||||||||||
| UniProtKB:F1QXN4 | InterPro | 1503 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kdm5bb-201
(1)
|
Ensembl | 6,670 nt | ||
| mRNA |
kdm5bb-202
(1)
|
Ensembl | 5,461 nt | ||
| mRNA |
kdm5bb-203
(1)
|
Ensembl | 600 nt | ||
| mRNA |
kdm5bb-204
(1)
|
Ensembl | 5,138 nt | ||
| mRNA |
kdm5bb-205
(1)
|
Ensembl | 1,199 nt |
Interactions and Pathways
No data available
Plasmids
No data available