Gene
kdm5bb
- ID
- ZDB-GENE-030424-1
- Name
- lysine demethylase 5Bb
- Symbol
- kdm5bb Nomenclature History
- Previous Names
-
- cb264 (1)
- jarid1bb
- plu1
- wu:fc44h11
- zgc:85741
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have histone demethylase activity (H3-dimethyl-K4 specific) and histone demethylase activity (H3-trimethyl-K4 specific). Predicted to be involved in chromatin remodeling. Predicted to localize to histone methyltransferase complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability; breast cancer; and malignant glioma. Is expressed in several structures, including hindbrain neural plate; musculature system; nervous system; neural tube; and solid lens vesicle. Orthologous to human KDM5B (lysine demethylase 5B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb264 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 65 | Alliance | Intellectual developmental disorder, autosomal recessive 65 | 618109 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR001606 | ARID DNA-binding domain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR003347 | JmjC domain |
| Domain | IPR003349 | JmjN domain |
| Domain | IPR004198 | Zinc finger, C5HC2-type |
| Domain | IPR013637 | Lysine-specific demethylase-like domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR047978 | Lysine-specific demethylase 5B, first PHD-finger |
| Domain | IPR047979 | Lysine-specific demethylase 5B, third PHD-finger |
| Domain | IPR047981 | Lysine-specific demethylase 5B, ARID domain |
| Domain | IPR048615 | Lysine-specific demethylase 5, C-terminal helical domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036431 | ARID DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | ARID DNA-binding domain | ARID DNA-binding domain superfamily | JmjC domain | JmjN domain | Lysine-specific demethylase 5B, ARID domain | Lysine-specific demethylase 5B, first PHD-finger | Lysine-specific demethylase 5B, third PHD-finger | Lysine-specific demethylase 5, C-terminal helical domain | Lysine-specific demethylase-like domain | Zinc finger, C5HC2-type | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:G1K2I1
|
1522 | |||||||||||||||
|
UniProtKB:Q6IQX0
|
1503 | |||||||||||||||
|
UniProtKB:A0A8M3BBT1
|
1521 | |||||||||||||||
|
UniProtKB:F1QXN4
|
1503 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kdm5bb-201
(1)
|
Ensembl | 6,670 nt | ||
| mRNA |
kdm5bb-202
(1)
|
Ensembl | 5,461 nt | ||
| mRNA |
kdm5bb-203
(1)
|
Ensembl | 600 nt | ||
| mRNA |
kdm5bb-204
(1)
|
Ensembl | 5,138 nt | ||
| mRNA |
kdm5bb-205
(1)
|
Ensembl | 1,199 nt |
Interactions and Pathways
No data available
Plasmids
No data available